摘要
A series of diclofenac derivatives were synthesized.The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3- L1 cells.The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drug rosiglitazone.
A series of diclofenac derivatives were synthesized.The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3- L1 cells.The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drug rosiglitazone.
基金
The research work was supported by National Natural Science Foundation(No.30960462)
Guizhou Social Development Scientific Foundation(No.2008-3039)
Governor's Foundation for Excellent Scientific and Educational Talents of Guizhou(No.2009-81)
Excellent Youth Scientific Talents Foundation of Guizhou(No.2009-24)
