摘要
The effective chlorolactonization of alkenoic acids with（diacetoxyiodo）benzene and lithium chloride under mild conditions have been studied.Experiments show that various 4-pentenoic acids react with（diacetoxyiodo）benzene and lithium chloride fluently in CH_3OH at room temperature,obtaining five-membered chlorolactones in good yields in short times.Other alkenoic acids,such as 3-butenoic acid and trans 3-hexenoic acid give some more complicated results,and 4-pentynoic acid provides a chloroenol lactone with Z configuration in 40%of yield.
The effective chlorolactonization of alkenoic acids with（diacetoxyiodo）benzene and lithium chloride under mild conditions have been studied.Experiments show that various 4-pentenoic acids react with（diacetoxyiodo）benzene and lithium chloride fluently in CH_3OH at room temperature,obtaining five-membered chlorolactones in good yields in short times.Other alkenoic acids,such as 3-butenoic acid and trans 3-hexenoic acid give some more complicated results,and 4-pentynoic acid provides a chloroenol lactone with Z configuration in 40%of yield.
基金
Financial support from the Zhejiang Province Natural Science Foundation of China(No.Y4080068)
