血管内皮生长因子和基质金属蛋白酶-9在军人非小细胞肺癌组织中的表达及临床意义

Expression of VEGF and matrix metalloproteinase-9(MMP-9) in military patients with primary non-small cell lung cancer(NSCLC) and Its clinical significance

目的探讨血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)在军人非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法用免疫组织化学方法检测35例非小细胞肺癌组织中VEGF和MMP-9蛋白的表达。结果 35例非小细胞肺癌和30例正常肺组织中VEGF、MMP-9表达阳性的例数分别为62.8%(22/35)、77.1%(27/35)和20.0%(6/30)、23.3%(7/30),差异有统计学意义。Ⅲ期肺癌VEGF、MMP-9表达的阳性率明显高于Ⅰ、Ⅱ期。有淋巴结转移癌的VEGF、MMP-9表达的阳性率明显高于无淋巴结转移的病例,差异有统计学意义(P<0.05)。结论 VEGF、MMP-9在非小细胞肺癌组织中的表达增多,可能参与了非小细胞肺癌浸润和转移。

Objective To explore the expression level of VEGF,MMP-9 in military patients with primary non-small cell lung cancer（NSCLC）.Methods The expression of VEGF,MMP-9 protein was detected in 35 NSCLC tissues by immunochemistry.Results The positive rate of VEGF,MMP-9 protein expression in NSCLC tissues was 62.8%（22/35）and 77.1%（27/35）,higher than those in normal lung tissue.The expression of VEGF,MMP-9 expression in NSCLC tissues of Ⅲ stage was significantly higher than that in NSCLC tissues ofⅠ、Ⅱstages（P〈0.05）.The expression of VEGF,MMP-9 in NSCLC tissues with lymph node metastasis was significantly higher than those in NSCLC tissues of N0 group（P〈0.05）.Conclusion The VEGF,MMP-9 expression are related to lymph node metastasis and TNM stages of lung cancer.VEGF,MMP-9 protein expression may beassociated with the invasion and progression of NSCLC.