不同剂量阿托伐他汀在TIA患者中的应用比较

Comparison of Different Doses of Atorvastatin in the Treatment of TIA Patients

目的探讨不同剂量阿托伐他汀在短暂性脑缺血发作（TIA）治疗和二级预防中的应用效果。方法 2008年1月-2008年10月TIA患者90例随机分为观察组和对照组各45例,两组均实施TIA常规治疗,对照组同时给予阿托伐他汀10 mg/d;观察组应用阿托伐他汀20 mg/d。结果两组患者近期治疗效果差异无统计学意义（P〉0.05）;随访1254个月,平均（26.34±8.56）个月,观察组TIA复发次数少、脑梗死比例低（P〈0.05）。两组药物不良反应比较差异无统计学意义（P〉0.05）,无需停用阿托伐他汀,未发现过敏反应及脑出血病例,无肾功能损害。结论在综合治疗的基础上应用20 mg阿托伐他汀比常规剂量10

Objective To study the different doses of atorvastatin in treatment and prevention of secondary effects in patients with transient ischemic attack（TIA）.Methods From January 2008 to October 2008,90 cases of TIA patients were randomly divided into two groups： the control group and observation group,with each group 45 cases.TIA conventional treatment was implemented in both groups,while the control group was given atorvastatin 10 mg/d,and the observation group atorvastatin 20 mg/d.Results There was no significant difference in treatment result between the two groups（P〉0.05）.In the following 12-54 months,[mean（26.34±8.56） months],fewer recurrent TIA and the lower proportion of cerebral infarction（P〈0.05） were found in the observation group.There was no significant difference（P〉0.05） in adverse drug reactions between the two groups,without disabling atorvastatin,no cases with allergic reactions and cerebral hemorrhage,and no renal dysfunction occurrec.Conclusion Based on the application of combined therapy of atorvastatin,20 mg dose was safe and better in treatment efficiency when compared with the dosage of 10 mg