高通量血液透析对严重肾衰竭的治疗分析

Clinical Application of High-Flux Hemodialysis in the Treatment of Patients with Severe Renal Failure

目的观察并分析高通量血液透析对严重肾衰竭患者的治疗效果。方法将76例严重肾衰竭患者随机平均分为高通量透析组和常规透析组两组,分别进行高通量透析或常规透析治疗,疗程为3个月。治疗结束后分析其疗效,并观察患者的临床表现、体征的改善情况和生化指标的变化情况。结果经3个月治疗后,高通量透析组患者的总有效率为78.9%,而常规透析组的为55.3%,两者间差异存在统计学意义。两组治疗前各项检测指标差异无统计学意义。经治疗3个月后,高通量透析组的β2-MG、Scr、BUN、24 h尿蛋白、Hb与治疗前比较差异有统计学意义(P<0.05),而A lb未见显著改变(P>0.05)。常规透析组的β2-MG、Scr、BUN、A lb、24 h尿蛋白、Hb均与治疗前存在显著性差异。组间比较,高通量透析组的β2-MG、24 h尿蛋白、Hb与常规透析组比较差异存在统计学意义(P<0.05)。而且高通量透析组的不良反应也较常规透析组的为轻。结论高通量血液透析可有效治疗并改善严重肾衰竭患者的情况。

Objective To study the effect of the high-flux hemodialysis in patients with severe renal failure.Methods 76 patients with severe renal failure were randomly divided into the high-flux hemodialysis group and the normal hemodialysis group,respectively.The efficacy,improvement of clinical manifestations,signs and changes in biochemical were detected and analyzed.Results After 3 months’ treatment,the total effective rates of the high-flux hemodialysis group and the normal hemodialysis group were 78.9% and 55.3% respectively.And there were significant differences between them.β2-MG,Scr,BUN,24h urine protein,Hb of the high-flux hemodialysis group were significantly changed without Alb.But all of the diameters of the normal hemodialysis group were significantly changed.β2-MG,24 h urine protein,Hb of the high-flux hemodialysis group were significantly changed compared with the normal hemodialysis group（P〈0.05）.Adverse reactions of the high-flux hemodialysis group was milder than that of the normal hemodialysis group.Conclusion The high flux hemodialysis was an effective treatment for severe renal failure and improving the patient’s condition.