摘要
目的观察并分析高通量血液透析对严重肾衰竭患者的治疗效果。方法将76例严重肾衰竭患者随机平均分为高通量透析组和常规透析组两组,分别进行高通量透析或常规透析治疗,疗程为3个月。治疗结束后分析其疗效,并观察患者的临床表现、体征的改善情况和生化指标的变化情况。结果经3个月治疗后,高通量透析组患者的总有效率为78.9%,而常规透析组的为55.3%,两者间差异存在统计学意义。两组治疗前各项检测指标差异无统计学意义。经治疗3个月后,高通量透析组的β2-MG、Scr、BUN、24 h尿蛋白、Hb与治疗前比较差异有统计学意义(P<0.05),而A lb未见显著改变(P>0.05)。常规透析组的β2-MG、Scr、BUN、A lb、24 h尿蛋白、Hb均与治疗前存在显著性差异。组间比较,高通量透析组的β2-MG、24 h尿蛋白、Hb与常规透析组比较差异存在统计学意义(P<0.05)。而且高通量透析组的不良反应也较常规透析组的为轻。结论高通量血液透析可有效治疗并改善严重肾衰竭患者的情况。
Objective To study the effect of the high-flux hemodialysis in patients with severe renal failure.Methods 76 patients with severe renal failure were randomly divided into the high-flux hemodialysis group and the normal hemodialysis group,respectively.The efficacy,improvement of clinical manifestations,signs and changes in biochemical were detected and analyzed.Results After 3 months’ treatment,the total effective rates of the high-flux hemodialysis group and the normal hemodialysis group were 78.9% and 55.3% respectively.And there were significant differences between them.β2-MG,Scr,BUN,24h urine protein,Hb of the high-flux hemodialysis group were significantly changed without Alb.But all of the diameters of the normal hemodialysis group were significantly changed.β2-MG,24 h urine protein,Hb of the high-flux hemodialysis group were significantly changed compared with the normal hemodialysis group(P〈0.05).Adverse reactions of the high-flux hemodialysis group was milder than that of the normal hemodialysis group.Conclusion The high flux hemodialysis was an effective treatment for severe renal failure and improving the patient’s condition.
出处
《中华全科医学》
2011年第5期742-743,共2页
Chinese Journal of General Practice
关键词
严重肾衰竭
高通量血液透析
治疗
Severe renal failure
High flux hemodialysis
Therapy