益赛普治疗强直性脊柱炎患者血液流变学观察

Changes of hemorheology in Patients with Ankylosing Spondylitis Treated with Etanercept

目的比较早中期强直性脊柱炎(ankylosing spondylitis,AS)患者在经益赛普治疗3个月前后血液流变学的变化,探讨益赛普对早中期AS患者血液流变学的影响。方法以141例早中期AS患者采用益赛普治疗3个月,治疗前后分别检测患者血液流变学指标,ESR,CRP和免疫球蛋白(IgA、IgG、IgM),并对两次结果进行比较。结果 AS患者在经益赛普治疗后,全血粘度值(从高切变率到低切变率)、血浆粘度值、红细胞压积、红细胞聚集指数和纤维蛋白原指标均有不同程度的回落(P<0.05)。ESR、CRP和免疫球蛋白(IgA、IgG、IgM)与治疗前均有显著下降(P<0.05)。结论经益赛普治疗的早中期AS患者血液流变学指标得到较好的改善,减少了其它疾病发生的可能性。AS患者治疗过程中血液流变学指标的变化能否成为指导临床治疗的依据之一值得我们继续探讨和研究。

Objective To compare the changes of hemorheology in the early and mid-patients with ankylosing spondylitis before and after three months treatment with Etanercept,and to explore the effects of Etanercept on hemorheology of patients with early and mid-AS.Methods 141 patients with early and mid-AS were treated with Etanercept for three months.The hemorheological indices in these patiens was examined before and after treatment,ESR,CRP and immunoglobulin（IgA,IgG,IgM） were compared between the two groups.Results After Etanercept treatment,the hemorheological indices in AS patients,whole blood viscosity（shear rate from high to low shear rate）,plasma viscosity,hematocrit,erythrocyte aggregation index,fibrinogen and etc,was declined in different degrees（P〈0.05）.Indices,ESR,CRP,immunoglobulin（IgA,IgG,IgM）,had significantly reduced（P〈0.05）.Conclusion The hemorheological indices had been ameliorated in patients with early and mid-AS treated with Etanercept as against before treatment and the likelihood of other disease had been reduced