洪灾区肾综合征出血热的流行病学研究(英文)

Epidemiological study on hemorrhagic fever with renal syndrome in flood areas

目的:了解洞庭湖区洪灾后肾综合征出血热的动物宿主及人群隐性感染情况。方法:采用夹夜法捕鼠,应用免疫荧光技术检测鼠肺肾综合征出血热抗原及人血清肾综合征出血热抗体。采用非条件logistic回归分析探索人群肾综合征出血热隐性感染的危险因素。结果:灾区、邻灾区及新建移民点的鼠密度分别为6.95%,6.28%及8.67%;3地区鼠带毒率分别为15.07%,9.25%和4.47%;灾区带病毒鼠指数最高(0.10);黑线姬鼠是优势宿主。灾区、邻灾区及新建移民点的人群肾综合征出血热标化抗体阳性率分别为4.49%,3.11%和3.13%。人群抗体阳性率无性别和年龄差异。多因素分析结果提示肾综合征出血热隐性感染的危险因素包括参加过冬修水利和家里采取过灭鼠措施。结论:洞庭湖区洪灾后,3个地区均存在带毒动物宿主鼠,鼠密度及鼠带毒率较高,人群免疫水平不高,提示洪灾区应加强监测并加强灭鼠和预防接种等综合措施以预防肾综合征出血热的发生。

Objective To investigate the infection of hemorrhagic fever with renal syndrome（HFRS） in host animals and inapparent infection of HFRS in general population in Dongting Lake areas after floods.Methods The night trapping method was used to capture rodents.The immunofluorescence assays were used to detect the hantavirus（HV） antigens and antibodies in rodents lung and in the serum of general population.Nonconditional logistic regression was applied to analyze risk factors for inapparent infection with HV.Results In flood region,draw-near flood region and new migration region,rodent density was 6.95%,6.28%,and 8.67%,respectively,and the virus-carrying rate in rodents was 15.07%,9.25%,and 4.47%,respectively.The virus-carrying rat index was the highest in flood region（0.10）.Apodemus agrarius was the dominant species.The standardized positive rate of HV antibody in general population from above mentioned regions was 4.49%,3.11%,and 3.13%,respectively.There was no significant difference among different age or gender groups.The results of logistic regression analysis indicated that people who were involved in construction of water conservancy facilities in winter or practice of rat extermination at home were the principal factors related to inapparent infection with HV.Conclusion The virus-carrying rate in main host animals of HV in the 3 regions is high,whereas the positive rate of HV antibody is low in general population.Comprehensive measures should be taken to prevent and control HFRS,such as reinforcing surveillance of HFRS,strengthening deratization,and preventive inoculation.