摘要
目的:探讨吸人糖皮质激素治疗稳定期慢性阻塞性肺疾病(COPD)患者的疗效。方法:将稳定期COPD患者随机分为两组,实验组在常规治疗基础上吸入糖皮质激素布地奈德,对照组仅采用常规治疗,疗程均为18个月。结果:实验组呼吸困难评分、6分钟步行距离、生活质量评分、第1秒用力呼气等指标均较对照组明显改善(P<0.05),且急性加重患者的门诊和住院人次较对照组少(P<0.05)。结论:长期吸人中等量糖皮质激素布地奈德可减轻稳定期COPD患者的临床症状,改善活动耐力、生活质量和肺功能,减少急性加重次数。
Objective：To investigate the cura- tive effects of inhaling glucocortieoid in pa- tients with stable COPD. Methods：Patients with stable COPD were randomly divided into 2 groups. The testing group was treated witll inhaling glueoeortieoid Budesonide basedon routine thempy and the contrast group was treated only by routine therapy. The course of treatment was 18 months. Results ：Patients in the testing group were significantly improved more than the contrast one on the measures of decompensation grade 6min walking distancelife quality grade and FEVI（ P 〈 0. 05 ）, Moreovertheout patient sandin patients with acute agggravation in the testing group were less than those in the contrastgroup （ P 〈 0. 05 ）. Conclusion： Inhaling moderate dose of glucoeortieoid Budesonide can alleviate clinical symptom, improve stamina, life quality and lung function and reduce the frequency of acute aggravation of stable COPD.
