马来酸桂哌齐特与B族维生素联合治疗糖尿病周围神经病变疗效观察

Clinic Observation Of Combined Therapeutic Effect of Cinepazide Maleate and Cobalamin on Diabetic Peripheral Neuropathy

目的评价马来酸桂哌齐特与B族维生素在2型糖尿病合并周围神经病变治疗中的疗效。方法采用随机对照方法对90例2型糖尿病合并周围神经病变患者疗效进行统计学分析。治疗组45例联合使用马来酸桂哌齐特与B族维生素,对照组45例单纯使用B族维生素治疗14 d。结果治疗组在改善临床症状,提高运动和感觉神经传导速度方面均优于对照组,差异有显著性意义(P<0.05)。结论马来酸桂哌齐特联合B族维生素对2型糖尿病合并周围神经病变治疗有明显疗效。

Objective To evaluate the therapeutic effect of cinepazide maleate（CM） and cobalamin on diabetic peripheral neuropathy（DPN）.Methods 90 patients of DPN were randomly divided into 2 groups including treatment group and contrasting group,each with 45 cases.Treatment group received the combined therapy of CM and Cobalamin,meanwhile contrasting group were administrated Cobalamin for 14 days.Compared the therapeutic effects respectively.Results The treatment group was better than the contrasting group in the fields of improving clinic symptoms and the nerve conduction speed of perceiving and moving（P〈0.05）.Conclusion Combined therapy of CM and Cobalamin could improve DPN symptoms obviously.