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水杨醛甘氨酸Schiff碱铜配合物的合成、结构、磁性及其化学核酸酶活性研究 被引量：2

Synthesis,Crystal Structure,Magnetic Properties,DNA Binding and Cleavage Activity of One Three-dimensional Glycine Schiff Base Copper(Ⅱ) Coordination Polymers
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摘要 合成了一个水杨醛甘氨酸Schiff碱铜配合物.X-射线单晶结构分析表明,铜离子通过配体羧基氧桥联形成一个三维的孔洞结构.采用电子吸收光谱、荧光光谱、电化学、凝胶电泳等方法,研究了配合物与DNA的相互作用.化学核酸酶作用机理研究表明,超氧阴离子自由基参与氧化断裂DNA反应. One glycine Schiff base copper（Ⅱ） complex[（CuL）_2]_n（H_2L is a Schiff-base ligand derived from the condensation reaction of N-（2-hydroxybenzaldehyde） and L-glycine,）, has been synthesized and characterized by single crystal X-ray differaction.The binding interactions of the complex with CT-DNA have been investigated by UV-visible spectra,fluorescence quenching method and cyclic voltammetry,which shows that the complex binds to CT-DNA with an intercalative mode.In addition,the DNA cleavage experiments have been also investigated by agarose gel electrophoresis.The complex shows oxidative DNA cleavage activity in the presence of H_2O_2/sodium ascorbate and the reactive oxygen species（ROS） responsible for the DNA cleavage is likely superoxide anion radical（·O_2^-）.
作者 高春艳 冯莉 卢静 王志刚 田金磊 顾文 阎世平
机构地区 南开大学化学系 天津中医药大学科研处
出处 《南开大学学报（自然科学版）》 CAS CSCD 北大核心 2011年第1期1-8,13,共9页 Acta Scientiarum Naturalium Universitatis Nankaiensis
基金 国家自然科学基金(20771063 90922032)
关键词 氨基酸Schiff碱 铜配合物 DNA切割 晶体结构 amino acid Schiff base copper complex DNA cleavage crystal structure
分类号 O614.81 [理学—无机化学]
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共引文献10

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南开大学学报（自然科学版）
2011年 第1期

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