摘要
目的检测脓毒症患者血清高迁移率族蛋白(HMGB1)水平,探讨HMGB1与急性病生理学和长期健康评价(APACHEⅡ评分)及多种临床参数的关系。方法收集2009年5月至2009年12月天津医科大学第二医院重症监护病房(ICU)收治的脓毒症患者发病24小时内临床及实验室参数,计算APACHEⅡ评分,采用酶联免疫吸附测定(ELISA)方法检测患者发病24小时内及对照组血清HMGB1水平。结果对照组HMGB1(44.8±16.2)μg/L,脓毒症组HMGB1(83.7±25.6)μg/L,严重脓毒症组HMGB1(146.0±32.8)μg/L,3组比较差异有统计学意义(P<0.05)。HMGB1水平与APACHEⅡ评分呈正相关(r=0.318,P<0.05),与其他临床参数未显示相关性(P>0.05),APACHEⅡ评分、多器官功能障碍综合征评分、血小板为影响预后的危险因素,而血清HMGB1水平不是影响预后的独立危险因素。结论脓毒症患者在发病24小时内HMGB1水平明显升高,在一定程度上反映脓毒症病情严重程度,但尚不能作为预测脓毒症预后的独立危险因子。
Objective To measure high mobility group protein B1(HMGB1) in serum of sepsis patients to investigate the relation between HMGB1 and other clinic indexes such as APACHEⅡ.Methods The selection included clinic and laboratory data of patients with sepsis who were admitted to ICU between May,2009 and Dec,2009 in 24 hours,APACHEⅡ was computed,serum HMGB1 levels were determined by ELISA.Results HMGB1 level of sepsis was(83.7±25.6) μg/L,severe sepsis(146.0±32.8) μg/L,which were significantly increased than that of controls(44.8±16.2) μg/L(F=11.590,P0.05).There was positive correlation between HMGB1 and APACHEⅡ(r=0.318,P0.05),no pertinence existed with other clinic data(P0.05).APACHEⅡ score,MODS score,platelet were risk factors of sepsis prognosis,while serum HMGB1 level was not an independant risk factor.Conclusion HMGB1 level increases in 24 hours after sepsis.It can reflect the state of illness with sepsis in a certain extent,but not an independant risk factor to predict the prognosis.
出处
《临床荟萃》
CAS
2011年第10期845-847,共3页
Clinical Focus