1Dong MJ,Peng B, Lin XT, et al. The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980- 2004 studies[J].Age Ageing, 2007,36 (6) : 619-624.
2Pietrzik C,Behl C. Concept for the treatment of Alzheimer's disease:molecular mechanism and clinical application[J]. Int J Exp Pathol,2005,86(3) : 173-185.
3American Psychiatric Association. Diagnostic and statistical manual of mental disorders[M]. 4th ed. Washington: American Psychiatric Press, 1994 : 147-154.
4McKhann G, Drachman D, Folstein M, et sl. Clinical diagnosis of Alzheimer' s disease: report of the NINCDS ADRDA work group under the auspices of department of health and human services task force on Alzheimer' s Disease[J]. Neurology, 1984,34 (7) :939-944.
5Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease[J]. Am J Psychiatry, 1984, 141 (11): 1356-1364.
6Folstein MF,Folstein SE,McHugh PR. "Mini Mental State " a practical method for grading the cognitive state of patients for the elinician[J]. J Psyehiatr Res, 1975,12(3) : 189-198.
7Lawton MP, Brody EM. Assessment of older people: self- maintaining and instrumental activities of daily living [J]. Gerontologist,1969,9 (3) :179-186.
2Masters C L,Multhaup G,Simms G,et al.Neuronal origin of a cerebral amyloid:neurofibrillary tangles of Alzheimers disease contain the same protein as the amyloid of plaque cores and blood vessels[J].EMBO J,1985,4:2757-63.
3Deshpande A,Mina E,Glabe C,et al.Different conformations of amyloid-beta induce neurotoxicity by distinct mechanisms in human cortical neurons[J].Neuroscience,2006,26(22):6011-8.
4Ida N,Hartmann T,Pantel J,et al.Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay[J].J Biol Chem,1996,271(37):22908-14.
5Cole S L,Vassar R.The Alzheimers disease β-secretase enzyme,BACE1[J].Mol Neurodegener,2007,2:22.
6Conrad C,Galea L A,Kuroda Y,et al.Chronic stress impairs rat spatial memory on the Y-maze and this effect is blocked by tianeptine pretreatment[J].Behav Neurosci,1996,110:1321-34.
7Weijers H G,Weyers P.Locomotor activity and defecation of rats o bserved alone and in pairs in repeated open-field sessions[J].Percept Mot Skills,1998,86(3):1179-84.
8Torreilles F,Touchon J.Pathogenic theories and intrathecal analysis of the sporadic from of Alzheimers disease[J].Progr Neurobiol,2002,66(3):191-203.
9Bruni A C.Cloning of a gene bearing missense mutations in early onsetfamilial Alzheimers disease:a Calabrian study[J].Funct Neurol,1998,13(3):257-61.
10Hsiao K,Chapman P,Nilsen S,et al.Correlative memory deficits,Aβ elevation and amyloid plaques in transgenic mice[J].Science,1996,274:99-102.