噻托嗅铵治疗稳定期慢性阻塞性肺疾病的疗效观察

The Curative Effect of Tiotropium Bromide in Treating Chronic Obstructive Pulmonary Disease

目的：观察吸入噻托嗅铵在稳定期慢性阻塞性肺病（COPD）的临床疗效。方法：将我院2009年1月~2010年12月就诊的确诊稳定期COPD患者60例,随机分为治疗组和对照组。对照组给予常规综合治疗,治疗组在此基础上给予吸入噻托嗅铵。结果：与治疗前相比,噻托溴铵组病人第1 s用力呼气容积（FEV1）和用力肺活量（FVC）均显著增加（P〈0.05）;治疗1年时,噻托溴铵组病人FEV1谷值明显上升（P〈0.05）,常见药物不良反应为口干（1例,4%）。结论：噻托溴铵是治疗COPD病人有效和安全的支气管扩张药物,能明显改善患者的临床症状。

Objective：To evaluate the clinical effect of tiotropium bromide in treating COPD patient at stable stage.Methed： 60 patients with COPD were randomly divided into 2 groups,patients in experimental group were treated with tiotropium bromide and those in control group were treated with conventional therapy,The spiromerty was conducted at before treatment and 1 year after treatment.Result： Compared with the control group,Forced expiratory volum in second（FEV1）,Forced vital capacity（FVC） were significantly increased after treatment in the tiotropium groups（P0.05）.The major adverse event in the tiotropium groups was dry mouth（4%）.Conclusion： Tiotropium bromide can effectively improve lung function and clinical symptoms in COPD patient.