普贝生与催产素用于足月妊娠引产的效果比较

The efficacy of PropessTM versus that of oxytocin for labor induction of full-term pregnancies

目的观察并比较普贝生和催产素用于足月单胎妊娠孕妇促宫颈成熟及引产的临床效果。方法选择2010年1-10月在本院分娩的80例具有引产指征的足月单胎，超声影像检查正常，无妊娠期合并症的孕妇作为研究对象，单纯随机分为两组，其中，实验组40例，阴道内使用普贝生栓剂，对照组40例使用小剂量催产素，比较两组宫颈Bishop评分及分娩结局。结果普贝生组宫颈成熟有效率为95％，小剂量催产素宫颈成熟有效率为42．5％。普贝生组经阴分娩28例，阴道分娩率70％，催产素组经阴分娩17例，阴道分娩率为42．5％。结论普贝生能显著促进足月单胎妊娠孕妇的宫颈成熟，增加顺产分娩率，其计划分娩效果明显优于催产素组，值得临床推广使用。

Objective To observe and compare the efficacy of PropessTM with that of oxytocin for cervical ripening and labor induction in pregnancies. Methods 80 pregnant women who gave birth during the period of January 2010 to October 2010 in our hospital were selected as the subjects. They were all full-term pregnant with induction indications and normal ultrasound images but no pregnancy complications. They were randomly assigned to receive PropessTM vaginal insert （ 40 women, study group ） or low-dose oxytocin （ 40 women, control group ） for cervical ripening and induction. The Bishop scores and birth outcomes were compared between the two groups when the trial was finished. Results The PropessTM for cervical ripening rate was 95%, low-dose oxytocin was 42.5%. 28 cases of 40 in the PropessTM were vaginal delivery, vaginal delivery rate was 70%, however, the oxytocin group 17 cases of 40 subjects were vaginal delivery, the vaginal delivery rate was 42.5%. Conclusions Compared with low-dose oxytocin the PropessTM can dramaticaly promote cervical ripening in full-term singleton preg- nant women, increase rates of vaginal delivery and it is better than low-dose oxytocin in the planned delivery, it＇s worthy of clinical use.