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胶质瘤患者血清IGFBP-2的临床意义

Significance of Serum Insulin-like Growth Factor Binding Protein-2 in Glioma
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摘要 目的探讨胰岛素样生长因子结合蛋白-2(IGFBP-2)在胶质瘤患者血清中的表达及其临床意义。方法健康体检者(对照组)20例,胶质瘤患者74例,其中Ⅳ级26例,Ⅲ级14例,Ⅱ级27例,Ⅰ级7例。采用酶联免疫吸附法(ELISA)检测血清IGFBP-2的浓度。结果胶质瘤Ⅱ级、Ⅲ级、Ⅳ级组浓度均高于对照组(P<0.05),Ⅳ级组浓度高于Ⅰ级、Ⅱ级、Ⅲ级组(P<0.05);Ⅳ级胶质瘤中,随着肿瘤的增大,IGFBP-2浓度不断增加;复发性肿瘤组IGFBP-2浓度显著高于未复发组(P<0.05)。结论监测血清IGFBP-2浓度对判断胶质瘤病变性质、恶性程度及复发具有一定的临床意义。 Objective To investigate the expression of serum insulin-like growth factor binding protein-2 （IGFBP-2） in the glioma patients and its clinical significance.Methods The Concentration of Serum IGFBP-2 was tested byenzyme linked immunosorbent assay（ELISA） in 20 healthy controls,and 74 cases of glioma（grade Ⅳ 26,grade Ⅲ 14,grade Ⅱ 27 and grade Ⅰ 7）.Results Serum IGFBP-2 concentration in gliomas of grade Ⅱ-Ⅳ were significantly higher than that of the controls（P 0.05）,that of grade Ⅳ were hiagher than those of the grade Ⅰ-Ⅲ （P 0.05） ;As the lesion increases,the IGFBP-2 concentrations continuously increased in grade Ⅳ gliomas;The serum IGFBP-2 level of patients with glioma relapse was higher than that in patients without relapse（P 0.05）.Conclusion The detection of IGFBP-2 concentration was beneficial for judging nature and malignant degree and relapse.
作者 马鹏举 冯大勤 黄玮 杨雷霆 秦坤明 廖声潮 余永佳
机构地区 广西医科大学第一附属医院神经外科
出处 《广西医学》 CAS 2011年第3期293-296,共4页 Guangxi Medical Journal
关键词 神经胶质瘤 胰岛素样生长因子结合蛋白质-2 酶联免疫吸附法 Glioma Insulin-like growth factor binding protein 2 Enzyme-linked immunobsorbent assay
分类号 R739.43 [医药卫生—肿瘤]
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参考文献12

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二级参考文献19

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广西医学
2011年 第3期

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