口腔鳞癌组织中ID-1的表达及其临床意义

Expression and clinical significance of ID-1 in oral squamous cell carcinoma

目的：探讨分化抑制因子-1（inhibitor of DNA bind-ing,ID-1）在口腔鳞状细胞癌（oral squamous cell carcinoma,OSCC）组织中的表达,并分析ID-1的表达水平与口腔鳞癌患者各临床病理特征及其预后的关系。方法：采用免疫组织化学方法检测80例口腔鳞癌患者癌组织及20例正常口腔黏膜组织中ID-1的表达。结果：①口腔鳞癌组织中可检测到ID-1的表达,而正常口腔黏膜组中未检测到ID-1表达（P〈0.001）。②高、中、低分化口腔鳞癌ID-1表达阳性率分别为50.00%、71.43%、88.89%（P〈0.05）;ID-1表达与口腔鳞癌的病理分级呈正相关（rs=0.389）。③ID-1表达阳性率在Ⅲ~Ⅳ期组、有颈部淋巴结转移组中分别明显高于Ⅰ~Ⅱ期组、无颈部淋巴结转移组（P〈0.05）。④ID-1阴性表达的口腔鳞癌患者3年生存率（64.29%）明显高于阳性者的32.25%（P〈0.05）。结论：口腔鳞癌组织中ID-1表达与肿瘤的分期、分化程度、淋巴结转移及预后有关,ID-1阳性表达可以作为判断口腔鳞癌患者预后的指标。

Objective：To investigate the expression of DNA-binding inhibitory factor 1（ID-1） in oral squamous cell carcinoma（OSCC） tissues and analyze the clinicopathologic features and outcomes of OSCC on basis of ID-1 expression.Methods：Immunohistochemical technique was used to detect the expression of ID-1 in human OSCC（n=80） and normal tissues（n=20）.Results：① ID-1 was detected in OSCC,and yet was absent in normal tissues（P〈0.001）.② ID-1 was positively expressed in cases of well differentiated（50.00%）,moderately differentiated（71.43%） and poorly differentiated（88.89%）（P〈0.05）,and showed positive correlation with pathological grade of OSCC（r=0.389）.③The expression rate of ID-1 in stage Ⅲ and Ⅳand cases with positive neck lymph node were significantly higher than that of stage Ⅰand Ⅱand those with negative neck lymph node（P〈0.05）.④ The 3-year survival in OSCC patients with ID-1 negative was significantly longer as compared with those with positive ID-1（64.29% vs.32.25%,P〈0.05）.Conclusion：ID-1 expression level in OSCC tissues is associated with tumor stage and differentiation,involvement of lymph node metastasis and prognosis,and it may serve as a potential marker to evaluate the prognosis of this disease.