摘要
目的评价托吡酯治疗精神病患者冲动激惹行为的临床效果。方法将46例具有激惹行为的精神病住院患者随机分为两组,在原用药物不变的情况下,分别加用含托吡酯或不含托吡酯的胶囊治疗,采用修订的外显攻击量表(MOAS)和简明精神症状量表(BPRS)定期作盲式评定。结果加用托吡酯组控制冲动激惹行为的有效率为62.50%,明显高于对照组的31.82%(P<0.01),且未出现明显药物副作用。结论对具有激惹行为的精神病患者,可加用托吡酯以降低其激怒和冲动行为。
Objective To investigate the effect of topiramate to treat violence behavior in psychiatric patients.Methods Using double-blind control method,46 violence behavior in psychiatric patients were enrolled.The examples were divided into two groups randomly,topiramate combining anti-psychiatrics of group and placebo combining anti-psychiatrics of group,assessing efficience by MOAS and BPRS.Results The effective rate was 62.50% in anti-psychiatrics addition topiramate and 31.82% in anti-psychiatrics addition placebo respectively.There was a significant difference between two groups（P0.01）.Topiramate had less side-effects.Conclusion Topiramate combining anti-psychiatrics is effective and safe on the treatment of violence behavior of psychiatric patients.
出处
《中国药业》
CAS
2011年第9期60-61,共2页
China Pharmaceuticals
关键词
托吡酯
精神病患者
激惹行为
topiramate
psychiatric patients
aggression
