阿昔洛韦与伐昔洛韦预防频发性生殖器疱疹复发作用比较研究

To comparative the effect of aciclovir and valaciclovir on preventing the recurrence of recurrent genital herpes

目的:比较2种抗病毒药物病毒抑制疗法预防频发性生殖器疱疹复发的临床效果。方法:将132例频发性生殖器疱疹患者(复发次数>6次/年)随机分成2组,Ⅰ组口服阿昔洛韦400 mg每日2次,连续服用6个月。Ⅱ组口服伐昔洛韦500mg,每日2次,连续服用3个月,第4、5个月口服500 mg,每日1次,第6个月口服500 mg,隔日1次。分别对用药过程中及用药6个月后的复发情况进行观察。结果:与治疗前相比,2种方案治疗后平均复发次数均明显减少,2组治疗前、后平均复发次数差异均有统计学意义(t=12.46,P<0.05)。伐昔洛韦组与阿昔洛韦组比较,前者显著减低无症状排毒情况(t=5.72,P<0.05)。结论:伐昔洛韦比阿昔洛韦不仅可以有效预防频发性生殖器疱疹复发次数,而且可以减少生殖器部位的无症状排毒情况。

Objective： To compare the clinical and virologic effects of aciclovir and valaciclovir administered as suppressive therapy for patients with genital herpes. Methods： Two randomized, standard-controlled studies comparing aciclovir 400mg twice everyday for 6 months with valaeiclovir 500mg twice everyday for 3 months then 500mg once daily for 2 months and 500mg once every other day in the last month were performed. Then, compare the recurrence before and after taking antiviral drugs for 6 months. Results： Two treatments were reduced the relapse frequency and significant difference was found between the two groups（t = 12.46, P 〈 0.05）. Signifi cant difference was also found between the two groups in reducing asymptomatic shedding（t = 5.72,P 〈 0.05）. Conclusions： Valaciclovir can not only reduce the more recurrence of genital herpes, but also reduce more genital track shedding as compared with aciclovir.