GnRH脉冲模式对FSH分泌的影响

The Effect of GnRH Impulse Mode on FSH

本文目的是进行GnRH脉冲模式对FSH分泌影响的研究。用GnRH以不同的脉冲振幅、不同的频率对GTH细胞进行刺激后,检测FSH的24 h分泌量。结果表明,FSH的24 h分泌量,以频率为120 min、振幅20 nmol/L时的GnRH脉冲模式为最高,并且随着GnRH刺激频率的增快或减慢,FSH的分泌量均呈逐渐减少趋势。所以,GnRH脉冲频率本身就是一个调控信号,不同脉冲频率GnRH对FSH表达有着明显不同的影响,在相同振幅条件下,低频脉冲刺激(120 min间隔)时FSH的分泌达到高峰。

This article aims to research the influence of GnRH impulse mode on the secretion of FSH. The stimulation experiment of GnRH at different frequencies and with different amplitude lasted 24 h, and then the secretory volume of FSH was detected. The result shows the secretory volume of FSH reaches the top when the frequency of GnRH impulse is 120 rain and the vibration amplitude of it is 20 nmol/L, moreover, with the hurrying up or the stepping down of the frequency of GnRH stimulation, the secretion of FSH is both reducing gradually. So, GnRH impulse frequency itself is a regulation signal, and the different impulse frequencies of GnRH have clearly different influence on the expression of FSH. In the condition of the same vibration amplitude, when the cells are stimulated by impulse at low frequency （at the interval of 120 min）, the secretion of FSH reaches the top.