摘要
目的:探讨大剂量丙种球蛋白治疗新生儿和ABO溶血病的临床疗效。方法:43例患儿分为对照组21例,治疗组22例。治疗组在对照组综合治疗基础上,给予静脉注射丙种球蛋白。两组均于治疗前和治疗后分别查血总胆红素、血红蛋白及网织红细胞。结果:治疗组降低血清胆红素疗效方面均明显优于对照组(P<0.01),血红蛋白水平与治疗前无显著性差异(P>0.05),对照组在治疗3～4天后血红蛋白水平显著低于治疗前(P<0.01)。结论:静脉注射大剂量丙种球蛋白辅助治疗新生儿ABO溶血可加速血清胆红素下降速度,防止胆红素脑病发生,减少换血机率,特别是对于没有换血条件的医院,有较高的临床使用价值。
Objective：To investigate the immunoglobulin treatment of neonatal ABO hemolytic disease of the clinical efficacy.Methods：43 patients were divided into control group,21 cases,the treatment group 22 cases.The treatment group in the control group based on the comprehensive treatment given intravenous immune globulin.Both groups before and after treatment in the treatment of each check serum total bilirubin,hemoglobin and reticulocytes.Result：the treatment group to reduce the efficacy of serum bilirubin were significantly better than the control group（P0.01）,hemoglobin levels before treatment there was no significant difference（P0.05）,the control group in the treatment of 3～4d after the hemoglobin level was significantly lower than that before treatment（P0.01）.Conclusion：Intravenous immunoglobulin treatment of neonatal ABO hemolytic support can accelerate the rate of decline of serum bilirubin to prevent bilirubin encephalopathy,reducing shake-up probability,especially for the conditions of the hospital is not shake-up,there is a high clinical value.
