减少移植胚胎数量对冻融胚胎移植结局的影响

Impact on outcome of frozen-thawed embryo transfer by reducing numbers of transferred embryos

目的探讨年龄〈35岁妇女，减少冻融胚胎移植数量对移植结局的影响。方法77例年龄〈35岁患者共进行冻融胚胎移植90个周期，采用慢速冷冻快速复苏法对胚胎进行冷冻及解冻，移植胚胎数量分别为2个胚胎（48个周期）和3个胚胎（42个周期），比较其移植结局，包括临床妊娠率、胚胎植人率和多胎妊娠率等。结果移植2个胚胎患者的胚胎复苏存活率、优质胚胎率、临床妊娠率、胚胎植入率和多胎妊娠率分别为88．9％、89．6％、37．5％、26．O％、38．9％，移植3个胚胎患者分别为88．1％、81．0％、42．9％、18．3％、16．7％；两者间分别比较，差异均无统计学意义（P〉0．05）。但移植2个胚胎者中无三胎妊娠发生，而移植3个胚胎者中发生2次三胎妊娠。结论冻融胚胎移植周期中，如果胚胎质量良好，年龄〈35岁妇女移植胚胎数量从3个减少至2个，并不会明显降低临床妊娠率，同时可减少三胎妊娠的发生。

Objective To study the impact on pregnant outcome of reducing the number of embryos transferred from three to two in women at age less than 35 who received frozen-thawed embryo transfer （FET）. Methods The analysis was performed on 90 FET cycles （77 infertile couples,less than 35 years old） with slow-freezing/rapid-thawing method, including 48 cycles with two embryos transferred and 42 cycles with three embryos transferred. The embryo survival rate, high quality embryo rate, clinical pregnancy rate, implantation rate and multiple pregnancies rate were analyzed. Results No significant differences in embryo survival rate （ 88.9% versus 88. 1% ）, high quality embryo rate （ 89. 6% versus 81.0% ）, clinical pregnancy rate （37.5% versus 42. 9% ）, implantation rate （26.0% versus 18.3% ） and multiple pregnancy rate （38.9% versus 16. 7% ） were observed between two and three embryos transferred group （all P 〉 0. 05 ）. However, there were 2 triple pregnancies in three embryos transferred group while none in two embryos transferred group. Conclusion Reducing the number of high quality embryos transferred from three to two in women at age of less than 35 years old who received FET, could decrease the incidence of triple pregnancy and keep the similar clinical pregnancy rate.