调节性T细胞与辅助性T细胞比例失衡在溃疡性结肠炎发病机制中的作用
摘要
溃疡性结肠炎(ulcerativecolitis,UC)是反复发作的以腹痛、腹泻、黏液脓血便为主要表现的炎症性肠病。目前普遍认为UC的发病机制与多种因素有关,其中免疫调节异常是UC研究最活跃的领域。既往研究认为辅助性T细胞1(Thelper,Th1)和Th2细胞亚群失平衡在UC的发病机制中起重要作用,但随着研究的深入,UC在某些状况下并不能用单一的Th1/Th2细胞的模式解释。
出处
《中华消化内镜杂志》
北大核心
2011年第4期214-216,共3页
Chinese Journal of Digestive Endoscopy
参考文献11
-
1Park H, Li Z, Yang X, et al. A distinct lineage of CIM^+ T cells regulatest issue inflammation by producing interleukin 17. Nat Immunol, 2005,6 : 1133-1141.
-
2Fuss IJ, Heller F, Boirivant M, et al. Nonclassical CDld-restricted NK T ceils that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest, 2004, 113: 1490-1497.
-
3Wong CK, Lit LC, Tam LS, et al. Hyperp roduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Imp lications for Thl7-mediated inflammation in autoimmunity. Clin Immunol, 2008, 127 : 385 - 393.
-
4Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4^+ ,CD25^+ ,regulatory T ceils. Nat Immunol, 2003, 4:330-336.
-
5Gavin MA, Rasmussen JP, Fontenot JD, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature, 2007, 445:771-775.
-
6Dong C. Th17 cells in development:an updated view of their molecular identity and genetic programming. Nat Immuno1,2008,8 : 337 -348.
-
7Estelle B,Thomas K, Mohamed O, et al. Induction and effector functions of Th17 Ceils. Nature,2008,453:1051-1057.
-
8Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1 beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol,2007 ;8:942-949.
-
9Wan YY, Flavell RA. Regulatory T cells, transforming growth factor-beta, and immune suppression. Proc Am Thorac Soc, 2007,4:271-276.
-
10Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-betal controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity,2007,26 : 579-591.
-
1于璐,张燕,陈程,崔海福,严兴科,王富春.针灸防治哮喘的免疫调节机制研究进展[J].长春中医药大学学报,2010,26(4):615-617. 被引量:9
-
2叶志健,季露露,刘伟娟.复方甘草酸苷对湿疹患者Th细胞免疫功能的影响[J].江西中医药,2009,40(12):45-46. 被引量:8
-
3孙少馨,徐杰,周玥琲,董玢,金秋硕,瞿幸,段行武,李玲玲.凉血解毒中药对寻常型银屑病Th1/Th2平衡的影响[J].北京中医药大学学报,2015,38(11):767-771. 被引量:23
-
4许东明,姚丽君.血吸虫感染虫卵肉芽肿形成及免疫调节的机制[J].中国人兽共患病学报,2006,22(5):464-466. 被引量:4
-
5李森娟.白头翁汤对溃疡性结肠炎患者CD4^+CD25^+Treg细胞、IL-10的影响[J].浙江中医杂志,2012,47(2):107-108. 被引量:9
-
6童瑶,倪力强,张宁霞,陈慧娟.疏肝理肺法对应激哮喘模型大鼠Th1/Th2细胞因子的影响[J].上海中医药杂志,2003,37(8):3-5. 被引量:2
-
7倪力强,张宁霞,童瑶,陈慧娟.小青龙汤对哮喘大鼠Th1/Th2型细胞因子水平的影响[J].辽宁中医杂志,2003,30(9):703-704. 被引量:27
-
8韩涛,兰咏梅,安冬青.舒康平喘胶囊对哮喘大鼠支气管肺泡灌洗液中细胞因子的影响[J].中国实验方剂学杂志,2007,13(1):52-54. 被引量:2
-
9宾博平,李明忠,殷丽.防哮饮早期干预治疗对哮喘小鼠Th1/Th2细胞因子水平的影响[J].新中医,2010,42(8):128-130. 被引量:9
-
10杨文浩,崔刘福.TIM蛋白的生物学特性及其与自身免疫病的关系[J].中国中医基础医学杂志,2007,13(8):632-634. 被引量:1