丹参注射液联合低分子肝素治疗肠系膜静脉血栓

Injection salviae miltiorrhiza combined with low molecular weight heparin to treat mesenteric venous thrombosis

目的 探讨丹参注射液联合低分子肝素（LMWH）治疗肠系膜静脉血栓（MVT）的疗效.方法 回顾性分析26例LMWH非手术治疗MVT病例.根据是否联合静脉注射丹参注射液分为A组（非用药组）和B组（用药组）,分析两组住院期间病死率、中转手术率和平均住院日.结果 A、B两组住院期间病死率分别为36.4%（4/11）vs 13.3%（2/15）,差异无统计学意义（P＞0.05）;中转手术率81.8%（9/11）vs 26.7%（4/15）,平均住院（15.0±4.1）d vs（11.1±2.9）d,差异均有统计学意义（P＜0.05）.结论 丹参注射液联合LMWH应用于非手术治疗MVT对改善中转手术率和缩短住院时间有一定临床价值.

Objective To investigate the effect of injection salviae mihiorrhiza （ISM） combined with low molecular weight heparin （LMWH） to treat mesenteric venous thrombosis （MVT）. Methods We analyzed 26 patients with MVT retrospectively, and all of them accepted primarily non - operation therapy with LMWH. According to the using of ISM or not, the patients were separated into two groups ： group A （ non - ISM ） and group B （ ISM ）. The mortality in the duration of hospital stay and the rate of turning to operation between the two groups were analyzed with Fisher^s exact test, and the mean duration of hospitalization was analyzed with Student＇s t - test. Results The mortality in the two groups was 36.4% （4/11 ）vs 13.3% （2/15）, and there was no significant difference in statistics （P 〉 0. 05）. Nine patients（81.8%, 9/11 ）in group A and four patients（26. 7%, 4/15）in group B turned to operation, and there was significant difference （ P 〈 O. 05 ）. The mean duration of hospitalization in two groups was （15.0 ±4. 1 ） days in group A vs （11.1 ±2. 9） days in group B, and there was significant difference （P 〈 0. 05 ）. Conclusion It is worthy in clinic to use ISM combined with LMWH for non - operation therapy of MVT in order to reduce the rate of turning to operation and the mean duration of hospitalization.