葡萄糖酸锌治疗婴幼儿急性腹泻疗效观察

THE EFFECT OF ZINC GLUCONATE ON INFANTS WITH ACUTE DIARRHEA

目的观察葡萄糖酸锌治疗婴幼儿急性腹泻的临床疗效,探讨其作用机制。方法将172例急性腹泻婴幼儿随机分为治疗组和对照组。两组均给予常规治疗,治疗组在此基础上加用葡萄糖酸锌治疗,剂量为≤6个月儿给予葡萄糖酸锌10 mg/d,>6个月儿给予葡萄糖酸锌20 mg/d,疗程均为14 d。比较两组治疗总有效率、临床症状消失时间及随访3个月腹泻再发生率。结果治疗组总有效率明显高于对照组(χ2=6.14,P<0.05),治疗组发热、腹泻及住院时间与对照组比较差异有显著性(t=2.976～5.907,P<0.01),而呕吐时间与对照组比较差异无显著性(t=0.532,P>0.05)。在随访3个月过程中,治疗组腹泻再发生率与对照组比较差异有显著性(χ2=4.40,P<0.05)。结论葡萄糖酸锌可有效治疗婴幼儿急性腹泻并预防3个月内腹泻的再次发生。

Objective To observe the clinical effect of zinc gluconate on infants with acute diarrhea and study its mechanisms. Methods This study consisted of 172 infants with acute diarrhea,who were randomly divided into treatment and control groups.Both groups received conventional therapy.In addition to that,zinc gluconate was given to patients in the treatment group for two weeks,10 mg/d for those below 6 months old and 20 mg/d for those over 6 months old.The total effective rate,symptom-disappearing time,and recurrence during a 3-month follow-up were compared between the two groups. Results The total effective rate of the treatment group was significantly higher than that of the control group（χ2=6.14,P0.05）.There were significant differences between the two groups in terms of fever,diarrhea,and hospital stay（t=2.976-5.907,P0.01）,but no significant difference in terms of vomiting between the two groups（t=0.532,P0.05）.During the follow-up duration,the recurrence rate of diarrhea in the treatment group was significantly lower than that of the control（χ2=4.40,P0.05）. Conclusion Zinc gluconate is effective in treating infants with acute diarrhea and preventing recurrence of the disease within three months.