沙美特罗联合N-乙酰半胱氨酸治疗COPD的疗效分析

Analysis on the treatment effect of COPD treated by Salmeterol combined with N-acetylcysteine

目的探讨沙美特罗联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病(COPD)的疗效。方法选择稳定期COPD患者80例,随机分为治疗组与对照组,各40例。对照组单纯采用沙美特罗吸入治疗,治疗组在对照组的基础上联合采用N-乙酰半胱氨酸口服。两组患者疗程均为4周。结果治疗后治疗组与对照组组间FEV1占预计值%和QOL评分差异有统计学意义(P<0.05);治疗后治疗组诱导痰上清液SOD、MDA与对照组比较差异有统计学意义(P<0.05)。结论沙美特罗联合N-乙酰半胱氨酸具有明显的肺功能改善作用,同时对体内氧化/抗氧化状态及其气道炎症具有较好的作用,是治疗COPD的有效联合用药方案。

OBJECTIVE To discuss the treatment effect of chronic obstructive pulmonary disease（COPD）treated by Salmeterol combined with N-acetylcysteine.METHODS 80 COPD patients in steable period were chosen out and sandomly devided into treatment and control group,each group 40 cases.Control group were treated with Salmeterol and treatment group were treated by Salmeterol combined with N-acetylcysteine.Treatment course of each group was 4 weeks.RESULTS After treatment,the percentage of FEV1 between two groups in predict value and QOL scoring variation had statistically significant（P0.05）.The difference of SOD and MDA in induced sputum supernatant of two groups had statistically significant（P0.05）.CONCLUSION Salmeterol combined with N-acetylcysteine could improve lung function obviously.It had good role on the vivo oxidant/antioxidant status and airway inflammation.Therefore,Salmeterol combined with N-acetylcysteine should be a effective united drug program to treat COPD.