步长脑心通在原发性高血压病中的运用及对C反应蛋白、一氧化氮的影响

The influence of C-reactive protein and nitric oxide in the patients of essential hypertension used Naoxintong

目的观察步长脑心通在原发性高血压病中的运用及对C反应蛋白(CRP)和一氧化氮(NO)的影响,探讨脑心通的作用机制。方法 120例原发性高血压病患者随机分为常规治疗组(n=60)及脑心通组(n=60)。常规治疗组应用降压药物治疗使血压控制在140/90 mmHg以下。不使用其他调脂、抗氧化药物、非类固醇类消炎镇痛药物;脑心通组在常规治疗基础上加用步长脑心通胶囊,疗程为4周。治疗前后测定CRP、NO。结果经治疗后CRP均有下降,NO均明显升高,脑心通组与常规治疗组比较,变化更明显(P<0.05)。结论步长脑心通胶囊治疗原发性高血压通过降低CRP水平,提高NO水平而起到抑制炎症,改善内皮功能等作用,对预防脑血栓形成是有效、安全的治疗手段。

OBJECTIVE To observe the influence of C-reactive protein（CRP） and nitric oxide（NO）in the patients of essential hypertension used Naoxintong,and to explore Naoxintong mechanism of action.METHODS 120 patients with primary hypertension were randomly assigned to conventional therapy group（n=60）and Naoxintong group（n=60）.Conventional treatment group used antihypertensive drug to control blood pressure below 140/90 mmHg.Without used other lipid-lowering,antioxidant drugs,non-steroidal anti-inflammatory drugs.Naoxintong group added Naoxintong besides the antihypertensive drug.Treatment for 4 weeks.Before and after treatment measured C-reactive protein（CRP）and nitric oxide（NO）.RESULTS After treatment,CRP decreased and NO obviously elevates in conventional therapy group and Naoxintong group.Naoxintong group compared with the conventional treatment group,the change is more obvious（P0.05）.CONCLUSION Naoxintong treatment of essential hypertension inhibits inflammation and improves endothelial function by lowering CRP levels,increased NO levels.Prevention of cerebral thrombosis is effective and safe treatment.