二甲双胍治疗新诊断2型糖尿病合并非酒精性脂肪肝疗效观察

The curative effect of metformin in newly diagnosed type 2 diabetes mellitus with non-alcoholic fatty liver

目的观察二甲双胍对新诊断2型糖尿病合并非酒精性脂肪肝的临床疗效。方法本院内分泌科住院新诊断2型糖尿病合并非酒精性脂肪患者72例,随机分为两组,A组(二甲双胍联合来得时治疗3月)38例和B组(单纯来得时治疗3月)34例,测定FPG,PPG,体质指数(BMI),TC,TG,ALT,AST,GGT,AKP,HbA1C。结果两组治疗后HbA1C,FPG,PPG,TG,ALT,AST,GGT,AKP较治疗前均有显著性下降(P<0.05),HbA1C,FPG,PPG,TG,ALT,AST,GGT,AKP两组治疗后比较有显著性差异(P<0.05),A组BMI较治疗前显著下降(P<0.05),B组治疗后BMI上升,但与治疗前差异无显著性(P>0.05),两组治疗后BMI比较有显著性差异(P<0.05),两组TC治疗后均轻度下降(P>0.05),治疗前后比较无显著性差异(P<0.05)。结论二甲双胍在临床治疗糖尿病合并非酒精性脂肪肝方面有较好的疗效。

OBJECTIVE To observe the effects of metformin in newly diagnosed type 2 diabetes mellitus with non-alcoholic fatty liver.METHODS Clinical effects of inpatient hospital endocrinology newly diagnosed type 2 diabetic patients with non-alcoholic fatty liver.72 patients were randomly divided into two groups.group A and group B,measured FPG,PPG,body mass index（BMI）,TC,TG,ALT,AST,GGT,AKP,HbA1C.RESULTS After treatment,HbA1C,FPG,PPG,TG,ALT,AST,GGT,AKP were significantly decreased than before treatment（P0.05）,BMI in group A was significantly decreased（P0.05）.CONCLUSION Metformin in the clinical treatment of diabetic patients with nonalcoholic fatty liver has a good effect.