3种用药方案治疗恶性疟疾的最小成本分析

Cost-minimization Analysis on 3 Kinds of Medicines in the Treatment of falciparum malaria

目的对比分析3种不同用药方案治疗恶性疟疾的最小成本。方法选择性地将无其他并发症的1440例恶性疟疾患者随机分为A组(青蒿琥酯片加阿莫地喹片)、B组(双氢青蒿素哌喹片)、C组(复方磷酸萘酚喹片),运用药物经济学方法进行回顾性分析。结果 A、B、C 3组有效率分别为98.75%、98.33%、98.54%,成本分别为45.8、48.7、24元。3组病例中,都有个别病例出现比较轻微的恶心、胃不适、谷丙氨基转移酶及谷草氨基转移酶一过性轻度升高等不良反应,停药后可自行恢复正常。结论 3组疗效比较无显著性差异(P>0.05),C组治疗方案成本最低,最为经济。

OBJECTIVE To compare and analyze the minimum cost of three kinds of different drugs in the treatment of falciparum malaria.METHODS 1440 cases of falciparum malaria patients without other complications were randomly divided into group A(Artesunate+Amodiaquine combination Antimalarial),group B(Dihydroartemisinin and Piperaquine phosphate tablets),group C(Compound Naphthoquine Phosphate tablets).Using economic methods to analyzed retrospectively.RESULTS Effective rate of A,B,C 3 group were respectively 98.75%、98.33%、98.54%,costs were 45.8、48.7、24yuan.In 3 groups,there were individual cases was relatively mild nausea,Upset stomach,ALT and AST transient mild increase and other adverse reactions;and Returned to normal after stopping.CONCLUSION Compared with the other two groups,there are no significant differences in efficacy in three groups(P>0.05);group C is the lowest-cost treatment options and the most economical one.