大学新生乙型肝炎病毒感染状况调查及分析

Analysis of the trend of hepatitis B virus infection in new students enrolled

目的:了解大学新生乙型肝炎(乙肝)病毒感染情况,为校园内乙肝的防治提供科学依据。方法:采集蚌埠医学院2009级3 120名新生清晨空腹静脉血,分别采用酶联免疫法、改良赖氏法、重氮法测定乙肝表面抗原(HBsAg)、丙氨酸氨基转移酶(ALT)和总胆红素(TBIL)。结果:3 120名新生中,HBsAg阳性99名,阳性率为3.17%;男、女生HBsAg阳性率分别为3.77%和2.82%,差异无统计学意义(P>0.05)。男、女生ALT异常率和TBIL异常率差异有统计学意义(P<0.01),ALT、TBIL异常者中男女生HBsAg阳性率差异无统计学意义(P>0.05)。结论:新生HBsAg携带率比社会人群的HBsAg携带率低,对有HBsAg阳性的学生应加强管理,对易感人群进行乙肝疫苗接种,防止乙肝在学校传播。

Objective：To investigate the trend of hepatitis B virus（HBV） infection in students enrolled in Bengbu Medical College in 2009 in order to provide scientific evidence for preventing and controlling HBV happening.Methods：Hepatitis B surface antigen（HBsAg）,alanine aminotransferase（ALT） and total bilirubin（TBIL） levels of fasting blood plasma form 3120 students enrolled in Bengbu Medical College in 2009 were detected by enzyme-linked immunoadsordent assay,improved Reitman method and diazo-reaction method respectively.Results：In 3120 freshmen,there were 99 students who determined with positive HBsAg expression,the HBsAg infection rate was 3.17%;but there was no statistical difference（P0.05） between the rate of male freshmen HBsAg infection（3.77%） and female freshmen HBsAg infection（2.82%）.The abnormal rate of ALT and TBIL concentrations in male freshmen had statistical difference（P0.01） compared with their abnormal rate of female freshmen,but there was no statistical difference（P0.05） between the rate of HBsAg infection in freshmen who detected with abnormal ALT and others who detected with abnormal TBIL.Conclusions：The rate of HBsAg infection in the freshmen of our college is much lower than that of the social crowd,and it is necessary to strengthen management of students who carried hepatitis B virus,inoculate hepatitis B vaccine for susceptible population,and prevent the spread of hepatitis B virus in college.