2型糖尿病肾病患者检测血清胱抑素C的意义

Significance of detection of serum Cystatin C in patients with type 2 diabetic nephropathy

目的探讨胱抑素C在2型糖尿病(T2DM)肾病早期检测的意义。方法将80例T2DM患者按糖尿病肾病(DN)诊断标准分为DN组与非肾病(NDN)组。另择52例健康人作为正常对照(NC)组。同时检测三组的糖化血红蛋白(HbA1c)、肌酐(Cr)、尿素氮(BUN)、胱抑素C(Cys C),并对比分析。结果三组HbA1c、Cr、BUN、Cys C值比较差异有统计学意义(P<0.01)。DN组Cys C水平均高于NDN组和NC组(P<0.01);NDN组和NC组的Cr、BUN、Cys C值相比差异无统计学意义(P>0.05);DN组和NDN组分别与NC组的HbA1c水平相比差异有统计学意义(P<0.05),而DN组和NDN组的HbA1c水平相比差异无统计学意义(P>0.05)。DN组的Cys C分别与BUN和Cr变量间都存在显著的正相关(r=0.542,P<0.05;r=0.781,P<0.01)。结论 Cys C是2型糖尿病肾病患者肾功能损害早期诊断的重要指标。

Objective To explore the significance of early detection of serum Cystatin C（Cys C） in type 2 diabetic nephropathy（T2DM）.Methods 80 diabetic patients with T2DM were divided into Group DN and Group NDN according to the BUN and Cr level with 53 healthy people as the control group.The HbA1c,BUN,Cr,Cys C in three groups were detected and analyzed.Results The value of HbA1c,Cr,BUN and Cys C in the 3 groups had significant difference（P〈0.01）.The Cys C level in Group DN was averagely higher than that in Group NDN and the control group（P〈0.01）.The value difference of Cr,BUN and Cys C in Group NDN and the control group had no statistical significance（P〈0.05）.The HbA1c level in Group DN and NDN suggested separate significant difference from that of the control group（P〈0.05）,while the HbA1c level between Group DN and NDN showed no difference（P〈0.05）.Cys C in Group DN separately had obvious positive correlation with the variables between BUN and Cr（r=0.542,P〈0.05;r=0.781,P〈0.01）.Conclusion Cys C can be a role indicator for early diagnosis of renal function impairment in T2DM.