卵巢上皮性癌组织中survivin与p53表达的研究

Study on expressions of survivin and p53 in epithelial ovarian cancer

目的探讨survivin、p53在卵巢上皮性癌组织中的表达及其临床意义。方法应用SP免疫组化法测定46例卵巢上皮性癌组织中survivin、p53的表达强度,并与临床指标进行对照分析,同期44例卵巢上皮性良性肿瘤为对照组。结果①survivin在卵巢上皮性良性肿瘤组织中的表达率为11.4%(5/44),在卵巢上皮性癌组织中的表达率为88.6%(39/46),两组比较有统计学差异(P<0.01);survivin表达强度与癌细胞分化程度以及是否有淋巴结转移存在相关性,细胞分化程度低、有淋巴结转移者表达强度高于细胞分化程度高、无淋巴结转移者;②p53在卵巢上皮性良性肿瘤组织中的阳性表达率为11.4%(5/44),在卵巢上皮性癌组织中的表达率为78.3%(36/46),两组比较有统计学差异(P<0.01);p53表达强度与卵巢癌的临床分期以及是否有淋巴结转移存在相关性,临床分期晚、有淋巴结转移者表达强度高于早期、无淋巴结转移者;③survivin、p53在卵巢上皮性癌组织中的表达存在正相关。结论 survivin、p53在卵巢上皮性癌组织中呈高表达,二者表达存在正相关,并且提示恶性程度高,预后不良。

Objective To explore the expression of survivin and p53 in epithelial ovarian cancer and their clinical significances. Methods Expression intensity of survivin and p53 were detected by immunohistochemistry in the tissues of 46 cases with epithelial ovarian cancer, the relationship between clinical and pathological characteristics with survivin and p53 expressions were analysed. The 44 cases with benign epithelial ovarian tumor were taken as controlled group. Results 1） The positive expression rate of survivin was 11.4% in benign epithelial ovarian tumer and 88.6% in epithelial ovarian cancer respectively, there was statistical difference between two groups （P〈0.01）. There was a relationship between expressive intention of survivin and differentiation of cancer cell and lymph node metastasis in epithelial ovarian cancer. The survivin expression was higher in lower differentiation and lymph node positive than that in higher differentiation and no lymph node metastasis. 2） The positive expression rate of p53 was 11.4% in benign epithelial ovarian tumer and 78.3% in epithelial ovarian cancer respectively. There was statistical difference between two groups （P〈0.01）. There was a relationship between expressive intention of p53 and clinical stage and lymph node transference in epithelial ovarian cancer. The expression was higher in late clinical stage and lymph node positive than that in early stage and lymph node negative; 3） There was a positive relationship between expression of survivin and p53 in epithelial ovarian cancer. Conclusion Survivin and p53 are high expression in epithelial ovarian cancer, which predict that the tumor have a high perniciousness level and poor prognosis.