窒息新生儿血清IL-18及尿NAG水平变化及意义

Serum level changes of interleukin-18(IL-18) and urineβ-N-acetyglocosamidase in neonates influenced by asphyxia,and their significances

目的探讨窒息缺氧对新生儿血清白细胞介素18(IL-18)与尿N-乙酰-β-D氨基葡萄糖酐酶(NAG)水平的影响。方法对28例窒息新生儿出生后第1天、治疗10天后血清IL-18、尿NAG进行测定。以20名健康新生儿作对照。结果重度窒息新生儿生后第1天血清IL-18为(175.46±41.24)pg/ml,显著高于健康新生儿的(63.29±14.28)pg/ml(P<0.01);轻度窒息组患者血清IL-18为(118.06±25.31)pg/ml,亦显著高于健康新生儿(P<0.05);治疗后两组窒息患者IL-18水平均显著下降(P<0.05)。窒息患者尿NAG与健康新生儿的比较显著升高(P<0.05)。窒自患者IL-18水平与尿NAG水平呈正相关(P<0.05)。结论窒息缺氧可导致新生儿IL-18与尿NAG水平升高;IL-18可能参与了窒息新生儿肾脏损伤的发病过程。

Objective To explore the influence of asphyxia on serum levels of interleukin-18 and urineβ- N-acctyglocosamidase （NAG） in neonates. Methods The level of serum interleukin-18 and urine NAG were determined in 28 asphyxial neonates on the day 1, day 10 and 20 normal neonates on the day 1 after birth, respectively. Results Level of IL-18 in neonates with the severe asphyxia[（175.46±41.24） pg/ml ]were significantly higher than those[（63.29±14.28）pg/ml] in the normal cases（P〈0.01）; The mild asphyxia[（118.06±25.31）pg/ml] were significantly higher than those in the normal cases （P〈0.05）; After a regular ten-days treatment of asphyxia, serum IL-18 levels decreased significantly. Compared with the day l,it has significant difference （P〈0.05）. NAG of the asphyxia neonates had a higher level than that of the control group and the difference was obvious（P〈0.05）. There were significant positive correlations between serum levels of IL-18 and urine NAG （P〈0.05）. Conclusion The higher levels of IL-18 and NAG can be induced by asphyxia in neonates. IL-18 could be involved in the pathogenesis of renal injury in asphyxia neonates.