C反应蛋白在慢性阻塞性肺疾病中的临床意义研究

Clinical Significance of C-reactive Protein in Patients with Chronic Obstructive Pulmonary Disease of Acute Exacerbation

目的观察C反应蛋白(CRP)在慢性阻塞性肺疾病(COPD)急性加重中的临床意义。方法选取56例COPD急性加重期患者,观察患者CRP水平、白细胞计数(WBC)并进行痰培养。结果 CRP的异常率为98%,明显高于WBC及痰培养的异常率;COPD Ⅰ级的患者CRP水平显著低于COPDⅡ、Ⅲ、Ⅳ级患者。COPDⅡ、Ⅲ、Ⅳ级患者中,随着气流受限程度的加重,CRP水平逐渐增高,差异有统计学意义(P均<0.05)。结论 CRP是反映COPD急性加重期患者早期感染的敏感指标;CRP与肺功能损害程度呈正相关,能够反应疾病严重程度。

Objective Clinical significance of C-reactive protein in patients with chronic obstructive pulmonary disease of acute exacerbation.Methods Selected 56 patients with acute exacerbation of COPD patients was observed in patients with CRP levels,white blood cell count（WBC） and the sputum culture.Results The abnormal rate of CRP is 98%,higher than WBC and sputum samples abnormal rate in acute exacerbation of COPD patients.Patients whose FEV1% were above 80% had lower serum CRP level than those whose FEV1% less than 80%.Serum CRP level increased with the increasing degree of airflow limitation.Conclusion CRP is a sensitive and specific index to the acute phase of COPD,CRP can reflect the lung function and elevated the severity of acute exacerbation.