(2,2-双二茂铁基丙烷)-6-甲酸及其衍生物的合成

SYNTHESIS(2,2-BISFERROCENYLPROPANE)-6-METHANOIC ACID AND ITS DERIVATIVES

2,2-双二茂铁基丙烷与邻氯苯甲酰氯进行Friedel-Crafts酰化反应,得到的一元酰化产物在叔丁醇钾的存在下解离为相应的一元羧酸;并以2,2-双二茂铁基丙烷-6-甲酸为原料合成了相应的酯、酰氯、酰胺和胺。通过元素分析、红外光谱、核磁共振氢谱对这些化合物的结构进行了表征。结果表明:2,2-双二茂铁基丙烷进行邻氯苯甲酰化时,酰化位置在6位或6′位;以乙二醇二甲醚为溶剂进行2,2-双二茂铁基丙烷-6-甲酸的合成,原料转化率和产率都达到85%以上。

In this paper, acylation of 2,2 - bisferrocenylpropane is carried out by means of o - chlorobenzoyl chloride in the presence of aluminum trichloride and methylene chloride. Furthermore, （ 2,2 - bisferrocenylpropane） - 6 - methanoie acid was synthesized from the acylate with t- C4H9OK in ethylene glycol dimethy ether as solvent. In addition, the corresponding carboxylic acid esters, acyl chloride, acid amides and amine were prepared with this earboxylic acid. These compounds were characterized by elemental analysis, IR spectrum and 1HNMR spectra. The results showed that ： 2, 2 - bisferroeenylpropane and o - ehlorobenzoyl chloride carry on the chemical reaction, the stereospeeific number is 6 or 6, taking ethyl diol dimethyl ether as the melting synthesize （2,2 - bisferroeenylpropane） -6 -methanoic acid, the raw material conversion rate and produce rate attain above 85% .