摘要
目的:观察不同剂量(>5 mg/d)叶酸对脑梗塞患者血浆同型半胱氨酸(Hcy)的影响。方法:选择120例血浆同型半胱氨酸增高的脑梗塞患者随机分为A、B、C三组,每组40例。用药剂量:A组给予叶酸5 mg/d,B组给予叶酸10 mg/d,C组给予叶酸20 mg/d,连续给药4周,治疗前后检测血浆Hcy浓度。结果:3组治疗后的血浆Hcy浓度明显下降,前后自身比较P<0.001。3组间比较P>0.05,无统计学意义。结论:叶酸治疗脑梗塞合并的高Hcy血症有明显效果,但叶酸剂量大于5 mg/d后改变剂量对于降低Hcy程度无明显差异。
Objective: To observe the effects of different dose ( 〉5 mg/d ) of folic acid on the plasma homocysteine in patients with cerebral infarction. Method: 120 patients with cerebral infarction and hyperhomocysteinemia were randomly divided into 3 groups, 40 cases in each group. A group was taken folic acid 5 mg/d, ; B group was taken by the treatments of folic acid 10 mg/d; C group was taken by the treatments of folic acid 20 mg/d; The plasma homocysteine (Hcy) concentration was detected before and after 4 weeks treatment. Result: After 4 weeks treatment, the level of plasma Hcy significantly decreased in 3 groups ( all P〈0.001 ) than the level of prior treatment. But there was no difference between 3 groups after the treatment (all P〉0.05 ). Conclusion: The plasma homocysteine in patients with cerebral infarction was decreased after the treatment of folic acid. The degree of the homocysteine decreased has no relationship with the doses ( 〉 5 mg/d) of the medicine.
出处
《河北医学》
CAS
2011年第4期458-459,共2页
Hebei Medicine
关键词
叶
酸
剂量
脑梗塞
同型半胱氨酸
Folic acid
Dose
Cerebral infarction
Homocysteine