噻托溴铵粉剂吸入联合布地奈德雾化吸入治疗COPD疗效观察

Effect of the Therapy of Budesonide Inhalation Associated with Tiotropium Bromide Inhalation on COPD

目的:观察噻托溴铵粉剂吸入联合布地奈德雾化吸入治疗慢性阻塞性肺疾病(COPD)的效果。方法:将我院2009年12月至2010年5月诊断的107例COPD患者根据病情分为急性加重期和稳定期两组[1]。两种不同病情患者均再随机分为治疗组与对照组,分别予以噻托溴铵联合布地奈德治疗和布地奈德单独治疗,治疗7d后,分别比较两种疗法患者前后的FEV1/FVC、血气分析及功能性呼吸困难分级变化。结果:COPD急性加重期患者中治疗组和对照组治疗前观察值无统计学差异(P>0.05),治疗后两组观察值有统计学差异(P<0.05)。COPD稳定期患者中治疗组和对照组呈现同样的统计学意义改变。结论:在单用布地奈德治疗慢性阻塞性肺疾病的基础之上联合噻托溴铵治疗,能够更为有效地改善患者的肺功能,提高患者的生活质量。

Objective： To observe the effect of the therapy of budesonide inhalation associated with tiotropium bromide inhalation on COPD. Method： 107 patients diagnosed with COPD between October,2009 and May,2010 in our hospital into quickly aggravating subgroup and stable subgroup. Patients in each sub-group were randomly divided into two settings, one setting received the therapy of budesonide inhalation associated with tiotropium bromide inhalation, the other one receiving only the therapy of budesonide inhalation as a control. At the beginning and after 7 days curing, We both made comparison of FEV1/FVC, blood gas analysis and changes in dyspnea grade between two settings. Result： Before the curing started, we found no Significant difference between two settings in each subgroup（ P〉0.05 ）, but after 7 days curing,the significant difference appeared （ P〈0. 05 ）. Conclusion： Pulmonary function and life quality of the COPD patients can be effectively improved after therapy of budesonide inhalation associated with tiotropium bromide inhalation .