摘要
巨自噬是一种普遍存在的,由溶酶体介导,降解长寿命蛋白质和细胞器的分解代谢过程。巨自噬对心脏疾病调节有双向作用:通过清除损伤的细胞器和蛋白质聚合物,维持内环境稳定,促进细胞存活;严重损伤时,巨自噬过度激活导致心肌细胞死亡。本文综述巨自噬在心脏疾病调节中的研究进展,包括巨自噬的形成和凋亡的关系,探讨巨自噬作为调节因子,对缺血-再灌注、心肌肥大和心力衰竭的双向作用,为疾病治疗开辟新思路。
Macroautophagy is a catabolism process and widely exists in organisms.It can degrade long-lived proteins and organelles.Numerous of evidence shows that macroautophagy is closely related with heart disease and plays bidirectional roles in its regulation.Macroautophagy can promote cell survival through the removal of damaged organelles and protein aggregates.However,excessive macroautophagy can lead to cell death when facing to serious damage.This paper reviews the research progress of macroautophagy in the regulation of heart disease,including macroautophagy formation,the relationship between macroautophagy and apoptosis,macroautophagy under the conditions of myocardial ischemia-reperfusion,hypertrophy and heart failure,in order to find a new method for the treatment.
出处
《生理科学进展》
CAS
CSCD
北大核心
2011年第2期81-85,共5页
Progress in Physiological Sciences
基金
国家自然科学基金(重点项目:30930105
面上项目:30873058
30770785)
国家重点基础研究发展计划(973计划)项目(2007CB512005)
美国中华医学基金会杰出教授奖(F510000/G16916404)资助课题
关键词
巨自噬
凋亡
心脏疾病
macroautophagy
apoptosis
heart disease
