摘要
双膦酸盐类药物是焦膦酸盐分子的稳定类似物,是抗骨吸收类药物,作用机制明确,近年来在临床上广泛应用。常用于治疗骨质疏松症、变形性骨炎、恶性肿瘤骨转移引起的高钙血症和骨痛症等难治性病症,收到良好效果。但是,治疗中由于选用适应证和使用浓度不同,治疗后出现一些并发症,特别是下颌骨坏死的报道。现就与双膦酸盐治疗相关的下颌骨坏死进行综述,供口腔科医师参考。
Bisphosphonates are stable pyrophosphate analogues and antiresorptive drugs with clear mechanism of action and extensive clinical application in recent years.Bisphosphonates are commonly used and effective in treating osteoporosis,osteitis deformans,hypercalcemia and ostalgia caused by bone metastasis of malignant tumors,and other refractory illness.However,reports of post-therapeutic complications,especially osteonecrosis of the mandible,are seen as results of different selections of indications and concentrations.In this article,bisphosphonates-induced osteonecrosis of the mandible is reviewed to provide reference for dentists in clinical practice.
出处
《医学综述》
2011年第8期1181-1183,共3页
Medical Recapitulate
关键词
双膦酸盐
下颌骨坏死
恶性肿瘤
骨质疏松
Bisphosphonates
Mandibular osteonecrosis
Malignant tumor
Osteoporosis
