摘要
糖尿病肾病(DN)的发病机制错综复杂,多元醇通路、蛋白激酶C、糖基化终产物、氧化应激等在DN的发生发展中起着重要作用。这些机制不是孤立存在的,它们相互影响、相互作用,共同参与了DN的发展。多元醇途径激活可能是慢性高血糖损害多种组织结构的启动和促进因素。而醛糖还原酶作为多元醇通路的关键酶,可能在其中起着重要的枢纽作用。
The pathogenesis of diabetic nephropathy（DN） is intricate and complex.Polyol pathway,protein kinase C,advanced glycation end products,and oxidative stress play an important role in the progression of DN.These mechanisms are not independent as they are inter-related and interacted in the pathogenesis of DN caused by chronic hyperglycemia.The activation of polyol pathway may be the initiating and promoting factor,whilst aldose reductase plays a pivotal role as a key regulatory.
出处
《医学综述》
2011年第8期1190-1192,共3页
Medical Recapitulate
