微淋巴管密度与乳腺浸润性导管癌淋巴结转移的相关性研究

Study of the Relationship between the Microlymphatic Density and Lymph Node Metastasis in Breast Invasive Ductal Carcinoma

目的探讨正常乳腺组织、乳腺浸润性导管癌组织内部、癌周围组织中微淋巴管密度(MLD)及其与相关病理参数之间的关系,分析浸润性导管癌淋巴结转移的可能机制。方法应用免疫组化S-P法检测以上三种组织中MLD。结果癌周围组织中MLD明显高于癌组织内部(P<0.05)和正常乳腺组织(P<0.05)。癌周围组织中MLD与组织学分级、淋巴结转移密切相关(P<0.05),而与患者的年龄、肿瘤的大小无关(P>0.05)。结论浸润性导管癌周围组织中MLD与淋巴结转移密切相关,是预测浸润性导管癌淋巴结转移的有效指标之一,有助于判断浸润性导管癌的预后。

Objective To investigate the density of lymphatic vessel in three kinds of breast tissles and the correlation between microlymphatic density（MLD）and traditional clinicopathological parameter,analyse the possible mechanism of lymph node metastasis in breast invasive ductal carcinoma.Methods The expression of D2-40 in three kinds of breast tissles was detected by immunohistochemical S-P method,by which the MLD was calculated.Results The peritumoral MLD was significantly higher than that intratumoral MLD（P0.05）and that in normal breast tissue（P0.05）.There was a positive correlation of peritumoral MLD with lymph node metastasis and histological grade（P0.05）,there was no statiatical significance between different size of tumor and age（P0.05）.Conclusion There was close relationship between the peritumoral MLD and lymph node metastasis and invision,it can be use as a marker to evaluate the lymph node metastasis and measure the prognosis of breast invasive ductal carcinoma.