摘要
目的探讨多发性骨髓瘤肾脏损害的临床特征及其发生的相关因素.方法 对多发性骨髓瘤患者肾脏损害的临床表现及实验室检查进行回顾性分析.结果 肾脏损害发生率42.2%,以慢性肾功能不全最常见.骨髓浆细胞数量、β2微球蛋白（β2-MG）及尿游离轻链与肾功能损害之间有显著相关性（P〈0.01）;贫血及多发性骨损害与肾功能损害之间有相关性（P〈0.05）.结论 骨髓浆细胞增殖、β2-MG及尿游离轻链可能是多发性骨髓瘤肾脏损害的主要原因.
Objective To investigate the clinical characteristics and the correlative factor of kidney lesion in muhiple myeloma. Methods Retrospective analysis was performed on the clinical characteristics and laboratory data of 45 MM patients. Results The incidence of kidney lesion was 42. 2% , the most common kidney lesion was chronic renal failure. There was a significant correlation between the quantity of bone marrow plasmacyte, β2 - microglobulin, urine Bence - Jones protein and renal functional lesion（P 〈 0. 01 ）. Anemia and bone lesion were correlated to kidney danmge（P 〈 0. 05）. Conclusion Proliferation of bone marrow plasmacyte,β2 - microglobulin and urine Bence - Jones protein are main causes of kidney lesion in multiple myeloma.
出处
《浙江临床医学》
2011年第4期385-387,共3页
Zhejiang Clinical Medical Journal
