地特胰岛素与门冬胰岛素强化治疗2型糖尿病疗效观察

Effect of Insulin Detemir Combined Aspart in Intensive Insulin Therapy of Type 2Diabetes

目的观察地特胰岛素联合门冬胰岛素强化治疗2型糖尿病患者的疗效。方法将118例口服降糖药物欠佳的2型糖尿病患者随机分为地特胰岛素联合门冬胰岛素组(N-D组),诺和灵R联合诺和灵N组(N-N组),连续治疗2周,分别于治疗前后测空腹血糖(FPG)、餐后2h血糖(2hPG)和空腹胰岛素(FINS),并分别计算HOMA-IR和HOMA-β,记录血糖达标时间、达标日胰岛素类似物用量和低血糖发生频率。结果 N-G组与N-N组FBG、2hPG、Homa-β和Homa-IR比较均无显著性差异,P>0.05;两组强化治疗前后组内比较FPG、2hPG、Homa-β和Homa-IR比较均为P<0.01;而N-G组的糖达标时间、胰岛素用量和低血糖发生率均较N-N组低,P<0.01。结论地特胰岛素联合诺和锐强化治疗可以明显改善胰岛B细胞功能,降低胰岛素抵抗,使多数口服降糖药物控制血糖欠佳的2型糖尿病患者血糖更加快速、安全达标。

OBEJECTIVE To observe the effect of Isnulin Detemir combined with Aspart insulin in intensive therapy of patients with type 2diabetes patients.METHODS 118 poor oral hypoglycemic drugs in patients with type 2 diabetes were assigned to group N-G or group N-N,Continuously for 2 weeks,and record the patients before and after treatment of blood glucose,2-hour postprandial blood glucose,Fasting insulin,Homa-IR,Homa-β,the number of days to compare standards,Standards on the Insulin dosages,the frequency of hypoglycemia.RESULTS Compared with two groups after intensive insulin therapy there were no significant difference in FBG,2 h PG,Homa-β,Homa-IR,P0.05.Each group before and after intensive treatment there were significant difference in FPG、2 h PG、Homa-β、Homa-IR,P0.01.The standard time of sugar N-D group faster than N-N group,P0.01,the Insulin dosage and the frequency of hypoglycemia N-G group were less than N-N group,P0.01.CONCLUSION Insulin Detemir combined aspart in intensive insulin therapy of type 2 diabetes can significantly improve the islet B cell function,reduce insulin resistance,So that the majority of oral hypoglycemic drugs control in type 2 diabetic patients with poor blood sugar more quickly and safety standards.