三磷酸胞苷二钠治疗新生儿缺氧缺血性脑病的临床分析及其对神经内分泌的影响

The Clinical Analysis of Sodium Cytidine Triphosphate Therapy on Neonatal Hypoxic Ischemic Encephalopathy and the Influence of Neuroendocrine

目的:观察三磷酸胞苷二钠(CTP)治疗新生儿缺氧缺血性脑病(HIE)的临床疗效及其对神经内分泌的影响。方法:将2009年6月-2010年6月收治的106例中、重度HIE患儿随机分为两组,各53例,对照组采用一般常规治疗,治疗组在此基础上采用CTP进行治疗,比较两组的临床疗效及主要体征和神经内分泌指标的变化。结果:治疗组意识恢复、反射恢复和肌张力恢复时间均明显短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后两组COR和NE水平均较治疗前明显下降,差异有统计学意义(P<0.01)。治疗组治疗后COR和NE水平明显低于对照组治疗后水平,差异有统计学意义(P<0.01)。结论:采用CTP对HIE患儿进行治疗,能够缩短意识恢复、反射恢复和肌张力恢复时间,并明显改善神经内分泌,值得在临床推广应用。

Objective：To observe the effect of Sodium Cytidine Triphosphate therapy on neonatal hypoxic-ischemic encephalopathy and the influence of neuroendocrine.Methods：From June 2009 to June 2010,106 cases with hypoxic ischemic encephalopathy were randomly devided into two groups,the control group given routine treatment,while the treatment group was given routine treament and Sodium Cytidine Triphosphate therapy.compared with two groups of clinical efficacy,main signs,and neuroendocrine indexes.Results：Recovering consciousness,reflex restore and muscle tension recovery time of the treatment group were significantly shorter than the control group,the difference showed statistically significant（P0.05）.Two groups of COR and NE level after the treatment was decreased obviously before treatment,The difference was statistically significant（P0.01）.After treatment COR and NE level of the treatment group was obviously lower than those of the control group after treatment level.The difference was statistically significant（P0.01）.Conclusion：The Sodium Cytidine Triphosphate treatment of hypoxic ischemic encephalopathy,can shorten the recovering consciousness,reflex restore and muscle tension recovery time,and obviously improved neuroendocrine,It＇s worthy of clinic application.