血浆正五聚蛋白3水平及总胆固醇与高密度脂蛋白胆固醇比值与冠状动脉狭窄程度的关系

The relationship between plasma PTX-3 together with TC/HDL-C and severity of coronary artery stenosis

目的 研究血浆正五聚蛋白3（PTX-3）和总胆固醇（TC）/高密度脂蛋白胆固醇（HDL-C）与冠心病患者冠状动脉狭窄程度的关系.方法 采集并分析2008年7月至2009年12月在中南大学湘雅二医院心内科住院的择期行冠状动脉造影的冠心病患者87例,据冠状动脉造影结果,将患者分为2组：次全闭塞组和非次全闭塞组,所有患者入院第2天清晨空腹取静脉血测定PTX-3和血脂水平,并进行统计分析.结果 次全闭塞组冠心病患者的PTX-3浓度显著低于非次全闭塞组[（4.6±1.6）μg/L比（5.9±2.0）μg/L,t=-3.380,P＜0.05）];TC/HDL-C比值显著高于非次全闭塞组（4.9±1.1比4.1±1.2,t=3.107,P＜0.05）.校正性别、老年、糖尿病、高血压等混杂因素后PTX-3＜5μg/L（OR=4.471,95%CI1.516～13.189,P＜0.01）及TC/HDL-C比值≥4（OR=5.087,95%CI：1.676～15.440,P＜0.01）冠心病患者冠状动脉易发生次全闭塞.结论 在冠心病患者中,血浆低水平PTX-3和高水平T℃/HDL-C比值可能与冠状动脉狭窄程度相关.

Objective To evaluate the impact of plasma pentraxin-3 （PTX-3） together with total cholesterol（ TC）/high-density lipoprotein cholesterol （HDL-C） on severity of coronary artery stenosis. Methods Eighty seven cases from Department of Cardiology of the Second Xiangya Hospital of Central South University from July 2008 to December 2009, accepted elective coronary angiography, were enrolled into the study and divided into two groups according to the results of coronary angiography： subtotal occlusion group and nonsubtotal occlusion group. All patients were hospitalized and fasting venous blood were extracted on the next morning for PTX-3 and lipids level measurement. The data were statistically analyzed. Results The PTX-3levels in patients with subtotal occlusion group were significantly lower than those in nonsubtotal occlusion group [ （4. 6 ± 1.6） μg/L vs. （5.9 ± 2. 0） μg/L, t = -3. 380, P 〈 0. 05） ]; TC/HDL-C levels in patients with subtotal occlusion group were significantly increased when compared with those in nonsubtotal occlusion group （4. 9 ±1.1 vs. 4. 1 ± 1.2, t = 3. 107 ,P 〈 0. 05）. After adjusting for sex, age, diabetes, hypertension, and so confounding factors, the patients with PTX-3 〈 5 μg/L（OR = 4. 471,95 % CI 1.516 - 13. 189, P 〈 0. 01） and TC / HDL-C ratio ≥4 （OR = 5.087,95% CI 1.676 - 15.440, P 〈0.01） were prone to become subtotal coronary occlusion. Conclusion Low plasma PTX-3 level and increased ratio of TC and HDL-C may be related with the severity of coronary artery stenosis in patients with coronary heart disease.