青地合剂对鼻咽癌放射治疗的增效减毒作用观察

THE EFFECTS OF QINGDI COMPOSITION ON SYNERGIA AND ATTENUATION OF RADIOTHERAPY FOR PATIENTS WITH NASOPAHRYNGEAL CARCINOMA

目的观察青地合剂在鼻咽癌放射治疗中增效减毒作用的效果。方法 84例确诊为鼻咽癌的病人随机分为研究组与对照组。研究组自放射治疗开始口服青地合剂至放射治疗结束。对照组自放射治疗开始口服维生素C片至放射治疗结束。两组病人均采用电子直线加速器常规分割外照射,鼻咽区DT 7 000 cGy,颈部预防照射区DT 5 000 cGy。两组均未联合化疗。结果研究组发生急性口腔炎的时间较对照组延迟(t=126.40,P<0.001);研究组口干发生率低于对照组(2χ=8.64,P<0.01);研究组的总有效率高于对照组(χ2=4.44,P<0.05)。结论青地合剂能推迟急性口腔炎的发病时间,减少口干发生率,提高局部控制率,减轻鼻咽癌放射治疗副作用。

Objective To observe the effects of Qingdi composition-Chinese traditional medicine-on patients undergoing radiotherapy for nasopharyngeal carcinoma（NPC）. Methods Eighty-four NPC patients were randomly divided into study group and control group.The patients in study group received Qingdi composition during the whole course of radiotherapy,and those in the control group received vitamin C tablet.Both groups were radiated using linear electron accelerator with routine dissection： nasopharynx area with radiation dosage of DT 7 000 cGy and cervix area with prophylactic radiation of DT 5 000 cGy.No chemotherapy was applied to either group. Results Compared with the control group,the occurrence of acute stomatitis in the study group was delayed（t=126.40,P0.001）;The incidence of dry mouth was lower（χ2=8.64,P〈0.01）;The total effective was higher（χ2=4.44,P〈0.05）. Conclusion Qingdi mixture can delay the onset of acute stomatitis and decrease the incidence of dry mouth,raise the local control rate and lessen the side effects of the radiotherapy.