基质金属蛋白酶-2和p185^(HER-2/neu)蛋白在卵巢癌中的研究进展

Research progress of MMP-2 and p185^(HER-2/neu) in ovarian cancer

基质金属蛋白酶-2(Matrix Metalloproteinase-2,MMP-2)是基质金属蛋白酶家族的重要成员,能降解明胶蛋白和Ⅳ型、V型胶原,在细胞外基质的降解过程中起着关键作用,能够促进肿瘤细胞发生侵袭和转移。p185HER-2/neu蛋白是一种相对分子质量185×103的跨膜糖蛋白,由HER-2/neu基因编码,属于酪氨酸激酶受体家族,p185HER-2/neu蛋白在人类多种癌症中存在扩增及过量表达,并与肿瘤的侵袭性表型及生存期短密切相关。就基质金属蛋白酶-2和p185HER-2/neu蛋白的生物学特性,与卵巢癌侵袭转移和预后的关系及MMP-2和p185HER-2/neu蛋白的研究情况等予以综述。

Matrix metalloproteinase-2（MMP-2）,which is a member of MMPs family,can degrade glutin and collagen type Ⅳ and V.Matrix metalloproteinase-2 plays an important role in the course of degeneration of extracellular matrix and contributes to high invasiveness and metastasis of tumor cells.p185HER-2/ neu is a 185000 glycoprotein related to transmembrane tyrosine kinase receptor,which is encoded by the HER-2/ neu gene.The amplification or enhanced transcription of the p185HER-2/ neu is associated with the oncogenesis or increased severity of several types of cancers.This article summarized biological characters of MMP-2 and p185HER-2/ neu,their role in the invasion,metastasis and prognosis of ovarian cancer,and recent development in clinical application.