期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MMP-2对人肾系膜细胞Fractalkine释放的影响 被引量：1

下载PDF
导出
摘要 目的观察基质金属蛋白酶-2(MMP-2)对人肾系膜细胞(HRMC)干预后上清液中趋化因子Fractalkine(Fkn)释放的影响。方法用不同浓度重组MMP-2干预不同状态下的HRMC,用ELISA法检测HRMC上清液中Fkn蛋白含量。结果上清液中Fkn蛋白含量随MMP-2浓度增加而降低(P均<0.05)。结论重组MMP-2可以降低上清液中Fkn蛋白含量。
作者 方铭 吴心池 黄文龙 施广德
机构地区 江阴市人民医院
出处 《山东医药》 CAS 北大核心 2011年第13期75-76,共2页 Shandong Medical Journal
基金 无锡市科技发展指导性计划项目(csz00804)
关键词 明胶酶A FRACTALKINE 肾系膜细胞 人
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献5

  • 1Elkington PT,O'Kane CM,Friedland JS.The paradox of matrix metalloproteinases in infectious disease[J].Clin Exp Immunol,2005,142(1):12-20.
  • 2Chafer A,Schulz C,Fraccarollo D,et al.The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions[J].Arterioscler Thromb Vasc Biol,2007,27(1):55-62.
  • 3杨益宁,孙子林,杨涛,马婵娟,马里,刘乃丰.糖基化终产物对人肾系膜细胞MMP-2表达的影响[J].东南大学学报（医学版）,2006,25(5):349-352. 被引量：7
  • 4Baricos WH,Cortez SL,Dahr SS,et al.ECM degradation by cultured human mesangial cells is mediated by PA/plasmin/MMP-2 cascade[J].Kidney Int,1995,47(4):1039-1047.
  • 5陈海燕,樊均明.Fractalkine及其受体CX3CR1与临床疾病[J].华西医学,2005,20(2):409-410. 被引量：4

二级参考文献32

  • 1赵志涛,于晓艳,李才,苗春生,崔伦文.糖基化终末产物对大鼠肾系膜细胞基质金属蛋白酶2活性和表达的影响[J].吉林大学学报（医学版）,2004,30(6):843-845. 被引量：9
  • 2顾秀锋,陆静,刘乃丰.氨基胍与葛根素对糖尿病大鼠肾脏结缔组织生长因子表达的影响[J].东南大学学报（医学版）,2005,24(1):13-16. 被引量：10
  • 3Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity[J].Immunity, 2000, 12: 121-127.
  • 4Garton KJ, Gough PJ, Blobel CP, et al. Tumor necrosis factor-a-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1) [J]. J Biol Chem, 2001, 276: 37993-38001.
  • 5Umehara H, Bollm ET, Okazaki T, et al. Fractalkine and vascular injury [J]. Trends Immunol, 2001, 22: 602-607.
  • 6Nishimura M, Umehara H, Nakayama T, et al. Dual functions of fractalkine/CX3CR1 in trafficking of circulating cytotoxic effector lymphocytes that are defined by CX3CR1 expression[J]. J Immunol, 2002, 138: 6173-6180.
  • 7Fraticelli P, Sironi M, Bianchi G, et al. Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses[J]. J Clin Invest, 2001, 107:1173-1181.
  • 8Umehara H, Goda S, Imai T, et al. Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1[J]. Immunol Cell Biol, 2001, 79: 298-302.
  • 9Kerfoot SM, Lord SE, Bell RB, et al. Human fractalkine mediates leukocyte adhesion but not capture under physiological shear conditions: a mechanism for selective monocyte recruitment [J]. Eur J Immunol, 2003, 33: 729-739.
  • 10Ancuta P, Rao R, Moses A, et al. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes[J]. J Exp Med, 2003, 197:1701-1707.

共引文献9

同被引文献29

  • 1徐海,张启高.系统性红斑狼疮合并心肌梗死6例病例报告[J].医学研究生学报,2011,24(10):117-118. 被引量：7
  • 2Koziolek MJ, Vasko R, Bramlage C, et al. The CX (3)C-che- mokine fractalkine in kidney diseases [ J ]. Mini Rev Med Chem, 2009, 9(10) : 1215-1228.
  • 3Umehara H, Bloom ET, Okazaki T, et al. Fractalkine in vascu- lar biology : from basic research to clinical disease [ J ]. Artefio- scler Thromb Vase Biol, 2004, 24( 1 ) : 34-40.
  • 4Jones BA, Beamer M, Ahmed S. Fractalkine/CX3CLl: a poten- tial new target for inflammatory diseases [ J ]. Mol Interv, 2010, 10(5) : 263-270.
  • 5D'haese JG, Demir IE, Friess H, et al. Fractalkine/CX3CR1 : why a single chemokine-receptor duo bears a major and unique therapeutic potential[ J]. Expert Opin Ther Targets, 2010, 14 (2) : 207-219.
  • 6Ceyhan GO, Deucker S, Demir IE, et al. Neural fraetalkine ex- pression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis [ J ]. Lab Invest, 2009, 89 ( 3 ) : 347-361.
  • 7Chu L, Li X, Yu W, et al. Expression of fractalkine ( CX3CL1 ) and its receptor in endotoxin-induced uveitis [ J ]. Ophthalmic Res, 2009, 42(3) : 160-166.
  • 8Higglns JP, Wang L, Kambham N, et al. Gene expression in the normal adult human kidney assessed by complementary DNA mi- croarray[J]. Mol Biol Cell, 2004, 15(2) : 649-656.
  • 9Katsuyama K, Fujinaka H, Yamamoto K, et al. Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in nor- real and proteinuric rat kidney glomerulus [ J ]. Nephron Exp Nephrol, 2009, 113(2) : e45-e56.
  • 10Hoffmann U, Bergler T, Segerer S, et al. Impact of chemokine receptor CX3CR1 in human renal allograft rejection [ J ]. Transpl Immunol, 2010, 23(4): 204-208.

引证文献1

二级引证文献1

山东医药
2011年 第13期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部