川芎嗪治疗2型糖尿病肾病38例观察

Observation on Diabetic Renopathy（38 cases）Treated with Ligustrazine

糖尿病合并糖尿病肾病（ＤＮ）患者３８例，在维持原降糖治疗方案不变的基础上，加用川芎嗪 ８０ｍｇ／日静脉滴注，连续 ３～４周，使用川芎芎嗪前后作相关检测并比较。结果使用川芎嗪后２４小时尿总蛋白排泄量及尿糖显著下降（Ｐ＜０．００１）．内生肌酐清除率显著上升（Ｐ＜０．０１，空腹血糖及餐后 ２小时血糖显著下降（分别为Ｐ＜０．０１，Ｐ<０．００１），血浆果糖胺显著下降（Ｐ＜０．００１），胰岛素敏感性指数增加（Ｐ＜０．０１）．血浆胰岛素水平无显著变化。提示川芎嗪对ＤＮ具有确切的治疗效果，并可增强糖尿病人胰岛素的敏感性，改善糖代谢。

Objective to study the effect of ligustrazine (Lig) on the treatment of dia-betic nephrosis. ( DN ) and glucose metabolism in type 2 diabetes mellitus (DM). Metohods The selection of thirty-eight (38) diabetic patients with DN was made. Admin-istering Lig 80mg each day with maintaining the original treatmetn not to be changed for 3～ 4 weeks, the related items (bolow) were compared before and after Lig. Results The re-sults showtd that total protein and glucose in 24h urine were reduced (P<0. 001). endoge-nous creatinine clerance rate (CCr) was in-creased (P <0. 01), the levels of fasting and 2h postprandial blood glucose were rduced (P <0. 01, P < 0. 001 separately), and fruc-tosamine was lesser, insulin -sensitiveity in-dex(ISI) was increated (P<0. 01),after ad-ministering Lig. The levels of plsama insulin were without statistcally significant dfference (P < 0. 05). Conclusion It is suggested that Lig. is a safe and efficiont drug for DN and can increas insulin-sensitivity of DM patients.