脑胶质瘤病人化疗行颈总动脉穿刺方法的探讨

Investigation on Chemotherapy with Common Carotid Artery Puncture in Brain Glioma Patients

为探讨方便、可靠的化疗穿刺法，提高化疗的安全性，分别用普通动脉穿刺法和留置针穿刺法对１０例脑胶质瘤病人行经颈总动脉化疗４０次。结果表明：两种方法在首次穿刺成功率上经统计学处理，χ２＝０５１３，Ｐ＞００５，无显著性差异。说明应用留置针穿刺法化疗不降低首次穿刺成功率。但在重复穿刺率及外漏率上经统计学处理，χ２＝９４５３、６８０５，均Ｐ＜００１，差异有非常显著性。提示：应用留置针法对保护颈总动脉及周围组织，降低重复穿刺及外漏率，减轻病人化疗时的痛苦，提高化疗效果有重要作用。

To investigate the simple and reliable puncture chemotherapy and enhance the safety of chemotherapy, chemotherapy via common carotid artery was performed on 10 patients with brain glioma for 40 times by using general artery puncture and retaining needle puncture respectively. The reselts demonstrated that there was no statistical difference in the first puncture successful rate between the two punctures (2=0513, P>005), suggesting that retaining needle puncture chemotherapy could not reduce the first puncture successful rate. However, there were statistical differences in repeat puncture rate and leakage rate (2=9453,6805, respectively, P<001). It was demonstrated that retaining needle puncture could prevent common carotid artery and its surrounding tissue, reduce repeat puncture rate and leakage rate, alleviate the pain of the patients during chemotherapy and increase the chemotherapeutic effects.