柔红霉素聚氰基丙烯酸正丁酯毫微粒制备工艺的优化

OPTIMIZATION OF CONDITIONS FOR DAUNORUBICINPOLYBUTYLCYANOACRYLATE NANOPARTICLES PREPARATION

用乳液聚合法制备柔红霉素聚氰基丙烯酸正丁酯毫微粒，在单因素试验基础上，通过系统全面反馈动态技术优化，确定了处方和制备工艺。载药毫微粒平均粒径６０ｎｍ，分布范围３０～２２０ｎｍ，表观包封率９６．３６％，表观载药量５５．３３％（ｇ／ｇ）；有效包封率７４．１１％，有效载药量４２．２５％（ｇ／ｇ）。

The daunorubicin polybutylcyanoacrylate nanoparticles(DNRPBCANP) was prepared by emulsion polymerization. An optimum condition was established by single factor test and multichannel feedback test. Under this optimum condition the DNRPBCANP can be successfully prepared. The median particle size was 60 nm with a range of 30￣220 nm.The apparent associating ratio was 96.36%.The apparent drug loading was 55.37%(g/g).The effective embedding ratio was 74.11%.The effective drug loading was 42.25%(g/g).